Chronic stress alters the immune response to influenza virus vaccine in older adults
Chronic stress alters the immune response to influenza virus vaccine in older adults
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DOI：
10.1073/pnas.93.7.3043
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发表时间：
1996-04-02
影响因子：
11.1
通讯作者：
Sheridan, J
中科院分区：
文献类型：
--
作者：
KiecoltGlaser, JK;Glaser, R;Sheridan, J
为了确定慢性压力源（照顾患有进行性痴呆的配偶）是否与流感病毒疫苗免疫应答受损有关，我们将32名照顾者的疫苗应答与32名性别、年龄和社会经济匹配的对照受试者进行了比较。通过ELISA和血凝抑制两种独立的方法评估，护理人员在接种疫苗后的抗体反应相对于对照组较差。照顾者的体外病毒特异性诱导的白细胞介素2和白细胞介素1 β水平也较低；白细胞介素6在两组间没有差异。这些数据表明，老年人对流感病毒疫苗免疫反应的下调与慢性应激源有关。这些结果可能会影响老年人对感染的易感性。
To determine whether a chronic stressor (caregiving for a spouse with a progressive dementia) is associated with an Impaired immune response to influenza virus vaccination, we compared 32 caregivers' vaccine responses with those of 32 sex-, age-, and socioeconomically matched control subjects. Caregivers showed a poorer antibody response following vaccination relative to control subjects as assessed by two independent methods, ELISA and hemagglutination inhibition. Caregivers also had lower levels of in vitro virus-specific-induced Interleukin 2 levels and interleukin 1 beta; interleukin 6 did not differ between groups. These data demonstrate that down-regulation of the immune response to influenza virus vaccination is associated with a chronic stressor in the elderly. These results could have implications for vulnerability to infection among older adults.