Increases in gastric acidity in response to electroacupuncture stimulation of the hindlimb of anesthetized rats
Increases in gastric acidity in response to electroacupuncture stimulation of the hindlimb of anesthetized rats
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DOI：
10.2170/jjphysiol.46.53
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发表时间：
1996-02-01
期刊：
影响因子：
--
通讯作者：
Hayashi, H
中科院分区：
文献类型：
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作者：
Noguchi, E;Hayashi, H
针灸治疗在传统东方医学中已被用作治疗胃肠疾病的物理疗法。本研究以麻醉动物为研究对象，通过改变动物条件，研究针刺刺激对胃酸分泌的影响。结果表明：1）电针刺激后肢可明显促进胃酸分泌，且与灌流液pH值有关; 2）坐骨神经失神经支配后，未观察到电针特异性反应。然而，灌流液的pH值下降响应于电针刺激后肢坐骨神经完整侧的同一只大鼠。3）迷走神经切断后，电针刺激对大鼠无反应，而交感神经切断后，电针刺激对大鼠有明显的增强反应。这些结果表明，针刺反应的主要传出通路是迷走神经，提示电针刺激迷走神经可使大鼠的神经元兴奋，麻醉大鼠的后肢增加胃酸分泌，其中躯体神经作为传入通路，迷走神经到胃的分支作为传出通路。
Acupuncture treatment has been used as physiotherapy to treat gastrointestinal disorders in traditional Oriental medicine. In the present study, we selected anesthetized animals as the subjects of this experiment in order to eliminate emotional factors, and investigated the responses to acupuncture stimulation at only a single point by changing animal conditions.1) There was marked enhancement of gastric acid secretion by electroacupuncture stimulation of the hindlimb based on pH values of the perfusate. However, the enduring response after the momentary initial decrease suggested the existence of humoral factors.2) The electroacupuncture-specific response was not observed in rats after sciatic nerve denervation. However, the pH values of the perfusate decreased in response to electroacupuncture stimulation of the hindlimb on the sciatic nerve intact side of the same rat. This suggests that the input pathway of acupuncture stimulation was a somatic nerve efferent pathway from the hindlimb.3) No response to electroacupuncture stimulation was observed in the rats after vagotomy, but a clear enhancement response was seen after sympathectomy, These findings show that the major efferent path of the responses to acupuncture stimulation is the vagus nerve.The results of this experiment suggest that electroacupuncture stimulation of the hindlimb of anesthetized rats increases gastric acid secretion with somatic nerves as the afferent pathway and branches of the vagus nerve to the stomach as the efferent pathway.