Contribution of resident and recruited macrophages in vascular physiology and pathology.
Contribution of resident and recruited macrophages in vascular physiology and pathology.
复制标题
驻留和招募的巨噬细胞在血管生理学和病理学中的贡献。
DOI：
10.1097/moh.0000000000000421
复制
发表时间：
2018
影响因子：
3.2
通讯作者：
Zhang,Li
中科院分区：
文献类型：
--
作者：
Zhang,Li
驻留的巨噬细胞在稳态下通过原位增殖来维持自身。损伤后，骨髓单核细胞可以贡献于成年动物中的常驻巨噬细胞池。胚胎和出生后衍生的常驻巨噬细胞是相似的，但不相同：前者是更有效的巨噬细胞，而后者是更有能力在主机防御。因此，特异性靶向这两种不同的驻留巨噬细胞群体可能会导致更好的治疗策略。
Resident macrophages maintain themselves via in-situ proliferation under steady state. Following injury, bone marrow monocytes can contribute to the resident macrophage pool in adult animal. Embryonically and postnatally derived resident macrophages are similar but not identical: the former are more efficient at efferocytosis, whereas the latter are more competent at host defense. Thus, specific targeting of these two different resident macrophage populations may lead to better therapeutic strategies.