Manifestation of arsenicosis patients and factors determining the duration of arsenic symptoms in Bangladesh
Manifestation of arsenicosis patients and factors determining the duration of arsenic symptoms in Bangladesh
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DOI：
10.1016/j.taap.2005.01.014
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发表时间：
2005-10-01
影响因子：
3.8
通讯作者：
Mori, M
中科院分区：
文献类型：
--
作者：
Hossain, MK;Khan, MMH;Mori, M
这项研究分析了孟加拉国 496 个乌普齐拉（分区）中的 6 个地区共 1,482 名砷中毒患者，这些患者是通过家庭筛查发现的，然后由由医务人员领导的训练有素的医疗团队确认。其中黑变病很常见（97%），但约三分之二（68.7%）的患者患有角化病。平均年龄为 36 岁，砷症状的平均持续时间为 3（中位）年。约50%的患者饮用管井水超过24年。黑变病与年轻患者（P = 0.031）、较浅的管井（P = 0.005）和结膜炎并发症（P < 0.001）显着相关。角化病还与年龄较大（P = 0.022）、管井较浅（P < 0.001）、结膜炎并发症（P < 0.001）、支气管炎（P < 0.001）、食欲不振（P < 0.001）和消瘦（P < 0.001）显着相关。砷症状的持续时间与年龄较大（P < 0.001）、男性（P = 0.002）、已婚（P < 0.001）、吸烟（P = 0.002）、饮用管井水的时间较长（P < 0.001）、结膜炎并发症（P = 0.002）、食欲不振（P < 0.001）、消瘦显着相关。 (P = 0.006)，以及砷中毒面临的社会问题(P = 0.040)。多变量比值比 (OR) 和 95% 置信区间 (CI) 表明角化病（OR = 2.00；95% Cl：1.56-2.56）与砷症状持续时间较长显着相关；食欲不振（OR = 1.40；95% Cl：1.12-1.74）是较长持续时间的显着并发症。同样，吸烟（OR = 1.33；95% Cl：1.06-1.68）与砷症状持续时间较长呈正相关。这些发现将帮助孟加拉国的政策制定者了解可能通过砷症状延长影响患者严重程度的因素。 (c) 2005 Elsevier Inc. 保留所有权利。
This study analyzed a total of 1482 arsenicosis patients living in 6 of 496 upzilas (sub-districts) of Bangladesh, who were identified through household screening and then confirmed by a trained medical team headed by medical officer. Melanosis was common (97%) among them but about two-thirds (68.7%) of the patients were suffering from keratosis. Average age was 36 years and average duration of arsenic symptoms was 3 (median) years. About 50% of the patients had been drinking tubewell water more than 24 years. Melanosis was significantly associated with younger patients (P = 0.031), shallower tubewell (P = 0.005), and complication of conjunctivitis (P < 0.001). Keratosis was also significantly associated with older age (P = 0.022), shallower tubewell (P < 0.001), complication of conjunctivitis (P < 0.001), bronchitis (P < 0.001), loss of appetite (P < 0.001), and wasting (P < 0.001). Duration of arsenic symptoms was significantly associated with older age (P < 0.001), male (P = 0.002), married (P < 0.001), smoking (P = 0.002), longer duration of consuming tubewell water (P < 0.001), complication of conjunctivitis (P = 0.002), loss of appetite (P < 0.001), wasting (P = 0.006), and social problem faced having arsenicosis (P = 0.040). Multivariate odds ratio (OR) and 95% confidence interval (CI) indicated that keratosis (OR = 2.00; 95% Cl: 1.56-2.56) was significantly associated with longer duration of arsenic symptoms; loss of appetite (OR = 1.40; 95% Cl: 1.12-1.74) was a significant complication for longer duration. Similarly smoking (OR = 1.33; 95% Cl: 1.06-1.68) was positively associated with longer duration of arsenic symptom. These findings will help the policy makers of Bangladesh to understand about the factors that may affect the severity condition of the patients through prolongation of arsenic symptoms. (c) 2005 Elsevier Inc. All rights reserved.