Diffuse optical imaging of the whole head
Diffuse optical imaging of the whole head
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DOI：
10.1117/1.2363365
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发表时间：
2006-09-01
影响因子：
3.5
通讯作者：
Boas, David A.
中科院分区：
文献类型：
--
作者：
Franceschini, Maria Angela;Joseph, Danny K.;Boas, David A.
近红外光谱（NIRS）和漫射光学成像（DOI）越来越多地用于检测大脑活动引起的大脑皮层血流动力学变化。直到最近，近红外仪器中数量较少的光电器件阻碍了对来自不同大脑区域的光信号的测量。我们的新DOI系统有32个检测器和32个源；通过将它们按特定的模式排列，我们可以覆盖成人头部的大部分。随着光电极数量的增加，我们可以同时从两个半球的前额叶皮层、感觉运动皮层和视觉皮层收集光学数据。我们描述了该系统，并报告了该系统在幻影以及人类受试者休息和视觉、运动和认知刺激期间的表征测量。利用该系统大量的源和检测器，我们探索了休息时生理信号的时空模式。这些由心脏、呼吸和血压调节产生的生理信号干扰了对脑刺激的血流动力学反应的测量。全头部光学测量，除了提供多个大脑区域对大脑激活的反应图外，还将更好地理解生理信号，最终导致更好的信号处理算法，以区分生理信号杂波和大脑激活信号。(c) 2006年光学仪器工程师学会。
Near-Infrared Spectroscopy (NIRS) and diffuse optical imaging (DOI) are increasingly used to detect hemodynamic changes in the cerebral cortex induced by brain activity. Until recently, the small number of optodes in NIRS instruments has hampered measurement of optical signals from diverse brain regions. Our new DOI system has 32 detectors and 32 sources; by arranging them in a specific pattern, we can cover most of the adult head. With the increased number of optodes, we can collect optical data from prefrontal, sensorimotor, and visual cortices in both hemispheres simultaneously. We describe the system and report system characterization measurements on phantoms as well as on human subjects at rest and during visual, motor, and cognitive stimulation. Taking advantage of the system's larger number of sources and detectors, we explored the spatiotemporal patterns of physiological signals during rest. These physiological signals, arising from cardiac, respiratory, and blood-pressure modulations, interfere with measurement of the hemodynamic response to brain stimulation. Whole-head optical measurements, in addition to providing maps of multiple brain regions' responses to brain activation, will enable better understandings of the physiological signals, ultimately leading to better signal processing algorithms to distinguish physiological signal clutter from brain activation signals. (c) 2006 Society of Photo- Optical Instrumentation Engineers.