The structure of cortical cytoplasm.
The structure of cortical cytoplasm.
复制标题
皮质细胞质的结构。
DOI：
10.1098/rstb.1982.0132
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Stossel,TP
中科院分区：
文献类型：
--
作者：
Stossel,TP
富含肌动蛋白的吞噬白细胞皮质细胞质形成假足，并通过产生定向推进力和收缩力来控制细胞的形状和运动。从白细胞中纯化的蛋白质形成并变形肌动蛋白基质。肌动蛋白结合蛋白（ABP）将肌动蛋白丝交联成具有垂直分支的三维晶格。这种结构在电子显微镜下可以看到，与肌动蛋白- abp矩阵的物理性质是一致的。凝胶在钙的存在下以高亲和力结合肌动蛋白丝的一端；另一种蛋白Acumentin以低亲和力结合另一端。这些蛋白质共同控制肌动蛋白丝的长度，从而调节肌动蛋白网络的扩张（推进）或崩溃。神经网络的组装状态也控制着基于肌凝蛋白的收缩力。拉锯战决定了晶格运动的方向，结构较小的区域倾向于向结构较大的区域移动。
Actin-rich cortical cytoplasm of phagocytic leucocytes forms pseudopodia and controls cell shape and movement by generating directional propulsive and contractile forces. Proteins purified from leucocytes form and deform an actin matrix. Actinbinding protein (ABP) cross-links actin filaments into a three-dimensional lattice with perpendicular branches. This structure, which can be visualized in the electron microscope, is consistent with physical properties of actin-ABP matrices. Gelsolin binds one end of actin filaments with high affinity in the presence of calcium; acumentin, another protein, constitutively binds the other end with low affinity. Together these proteins can control actin filament length and thereby regulate expansion (propulsion) or collapse of the actin network. The assembly state of the network also controls myosin-based contractile forces. A tug-of-war decides the direction of lattice movement, regions of lesser structure tending to move toward regions of greater structure.