Comparison of therapeutic effects of liposomal Tranexamic Acid and conventional Hydroquinone on melasma
Comparison of therapeutic effects of liposomal Tranexamic Acid and conventional Hydroquinone on melasma
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DOI：
10.1111/jocd.12152
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发表时间：
2015-09-01
影响因子：
2.3
通讯作者：
Jabari, Asma
中科院分区：
文献类型：
--
作者：
Banihashemi, Mahnaz;Zabolinejad, Naghmeh;Jabari, Asma
背景黄褐斑是最常见的导致皮肤变黑的美容疾病之一。尽管有多种治疗方法可供选择，但没有一种方法能令人满意地用于治疗这种病症。据报道，氨甲环酸 (TA) 是一种纤溶酶抑制剂，局部注射或口服和外用形式可改善黄褐斑。目的本研究的目的是比较脂质体氨甲环酸和传统对苯二酚对黄褐斑的治疗效果。方法30 名患有双侧黄褐斑的女性参加了一项持续 12 周的分面试验。除了早上指定的防晒霜外，患者每天两次盲目地将 5% 外用脂质体 TA 和 4% 对苯二酚霜涂抹在脸部的指定一侧。每次就诊时，使用 MASI（黄褐斑面积和严重程度指数）分别测量每侧的皮肤色素沉着，并每月测量一次，直至疗程结束后一个月。数据从患者档案中获取，并使用 SPSS 软件、配对样本 t 检验和重复测量方差分析进行统计分析。结果 23 名患者完成了研究。治疗两侧的平均 MASI 分数均显着降低（P
BackgroundMelasma is one of the most common cosmetic disorders with skin darkening. Although several treatment modalities are available, none is satisfactorily used in management of this condition. Tranexamic acid (TA), a plasmin inhibitor, is reported to improve melasma when injected locally or used as oral and topical forms.AimThe aim of this study was to compare therapeutic effects of liposomal tranexamic acid and conventional hydroquinone on melasma.MethodsThirty women with bilateral melasma were enrolled in a split-face trial lasting 12weeks. Patients blindly applied 5% topical liposomal TA and 4% hydroquinone cream, to the designated sides of the face twice daily in addition to the assigned sunscreen in the morning. Skin pigmentation was measured using MASI (Melasma Area and Severity Index) at each visit separately for each side at the base line and every month until one month after treatment course. Data were obtained from patients file and were analyzed statistically using SPSS software, paired samples t-test, and repeated measured ANOVA.ResultsTwenty-three patients completed the study. The mean MASI scores significantly reduced in both treated sides (P