Intestinal microbiota and its relationship with necrotizing enterocolitis.
Intestinal microbiota and its relationship with necrotizing enterocolitis.
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DOI：
10.1038/pr.2015.97
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发表时间：
2015-09
影响因子：
3.6
通讯作者：
Denning PW
中科院分区：
文献类型：
--
作者：
Patel RM;Denning PW
坏死性小肠结肠炎是早产儿发病和死亡的主要原因。出生后，新生儿肠道必须获得健康的肠道细菌补充。这一关键过程的中断或延迟，导致肠道微生物定植的缺陷或异常，已被认为是NEC发病机制中的关键风险因素。相反，肠道菌群的有益补充可以保护未成熟的肠道免受炎症和损伤。旨在提供或恢复肠道细菌健康补充的干预措施，如益生菌疗法，是目前预防NEC最有希望的治疗方法。将肠道微生物群的平衡从致病性细菌转变为保护性细菌补充可以保护肠道免受炎症和随后导致NEC的损伤。本文就早产儿肠道菌群与NEC的关系作一综述。
Necrotizing enterocolitis is a leading cause of morbidity and mortality in infants born prematurely. After birth, the neonatal gut must acquire a healthy complement of commensal bacteria. Disruption or delay of this critical process, leading to deficient or abnormal microbial colonization of the gut, has been implicated as key risk factor in the pathogenesis of NEC. Conversely, a beneficial complement of commensal intestinal microbiota may protect the immature gut from inflammation and injury. Interventions aimed at providing or restoring a healthy complement of commensal bacteria, such as probiotic therapy, are currently the most promising treatment to prevent NEC. Shifting the balance of intestinal microbiota from a pathogenic to protective complement of bacteria can protect the gut from inflammation and subsequent injury that leads to NEC. Herein, we review the relationship of intestinal microbiota and NEC in preterm infants.