Asymmetric synthesis of aerothionin, a marine dimeric spiroisoxazoline natural product, employing optically active spiroisoxazoline derivative
Asymmetric synthesis of aerothionin, a marine dimeric spiroisoxazoline natural product, employing optically active spiroisoxazoline derivative
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DOI：
10.1016/j.tetlet.2005.11.097
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发表时间：
2006-01-30
影响因子：
1.8
通讯作者：
Nishiyama, S
中科院分区：
文献类型：
--
作者：
Ogamino, T;Obata, R;Nishiyama, S
以旋外消旋螺异恶唑啉衍生物8为原料，首次成功合成光学纯的(+)-和(-)-航空硫蛋白(1)。通过(+)-和(-)-8与相关衍生物的比较，确定了天然(+)-1的绝对构型。(c) 2005 Elsevier Ltd版权所有。
Successful first synthesis of optically pure (+)- and (-)-aerothionins (1) from the racemic spiroisoxazoline derivative 8 has been accomplished. The absolute configuration of natural (+)-1 was determined by comparison of (+)- and (-)-8 with related derivatives. (c) 2005 Elsevier Ltd. All rights reserved.