Improved survival of colon cancer due to improved treatment and detection: a nationwide population-based study in The Netherlands 1989-2006
Improved survival of colon cancer due to improved treatment and detection: a nationwide population-based study in The Netherlands 1989-2006
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DOI：
10.1093/annonc/mdq227
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发表时间：
2010-11-01
影响因子：
50.5
通讯作者：
Coebergh, J. W. W.
中科院分区：
文献类型：
--
作者：
van Steenbergen, L. N.;Elferink, M. A. G.;Coebergh, J. W. W.
背景：我们描述了1989-2006年期间荷兰结肠癌治疗随时间的变化及其对生存率的影响。患者和方法：1989-2006年期间荷兰所有103744例浸润性结肠癌患者纳入研究。数据来自荷兰癌症登记处。分析治疗随时间的趋势，并进行多变量相对生存分析。结果：III期患者给予辅助化疗= 75年。在IV期患者中，原发肿瘤的切除率从72%下降到63%，而化疗给药率从23%增加到64%
Background: We described changes in treatment of colon cancer over time and the impact on survival in The Netherlands in the period 1989-2006.Patients and methods: All 103 744 patients with invasive colon cancer during 1989-2006 in The Netherlands were included. Data were extracted from The Netherlands Cancer Registry. Trends in treatment over time were analysed and multivariable relative survival analysis was carried out.Results: The administration of adjuvant chemotherapy in stage III patients = 75 years. Among stage IV patients, resection rates of the primary tumour decreased from 72% to 63%, while chemotherapy administration increased from 23% to 64% in those