Particle therapy for mucosal melanoma of the head and neck
Particle therapy for mucosal melanoma of the head and neck
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DOI：
10.1007/s00066-013-0489-9
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发表时间：
2014-02-01
影响因子：
3.1
通讯作者：
Fuwa, N.
中科院分区：
文献类型：
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作者：
Demizu, Y.;Fujii, O.;Fuwa, N.
目的.回顾性分析在兵库离子束医疗中心使用质子或碳离子治疗头颈部粘膜黑色素瘤（HNMM）后的治疗结果，并比较质子治疗（PT）和碳离子治疗（CIT）。分析了2003年10月至2011年4月期间接受PT或CIT治疗的62例无转移HNMM患者的数据。患者中位年龄为70.5岁（范围33-89岁）。在所有患者中，33例（53%）接受了PT，29例（47%）接受了CIT。两种离子类型均使用65或70.2 GyE的26个级分方案。中位随访时间为18.0个月（范围5.2-82.7个月）。所有患者的1-/2年总生存率（OS）和局部控制率（LC）分别为93%/61%和93%/78%，PT患者分别为91%/44%和92%/71%，CIT患者分别为96%/62%和95%/59%。PT和CIT之间未观察到显著差异。8例患者（PT：5，CIT：3）观察到局部复发，29例患者（PT：18，CIT：11）发生远处转移。急性反应是可以接受的，所有患者都完成了计划的放疗。至于晚期毒性，5例患者（PT：3例，CIT：2例）观察到3级或3级以上事件，但PT和CIT之间未观察到显著差异。我们的单机构回顾性分析表明，HNMM的粒子治疗实现了良好的LC，但OS不令人满意。PT和CIT在疗效或毒性方面均无显著差异。
Purpose. To retrospectively analyze treatment outcomes after particle therapy using protons or carbon ions for mucosal melanoma of the head and neck (HNMM) at the Hyogo Ion Beam Medical Center, as well as to compare proton therapy (PT) and carbon ion therapy (CIT).Patients and methods. Data from 62 HNMM patients without metastasis, treated with PT or CIT between October 2003 and April 2011 were analyzed. Median patient age was 70.5 years (range 33-89 years). Of the total patients, 33 (53 %) had received PT and 29 (47 %) had undergone CIT. Protocols for 65 or 70.2 GyE in 26 fractions were used for both ion types.Results. Median follow-up was 18.0 months (range 5.2-82.7 months). The 1-/2-year overall survival (OS) and local control (LC) rates were 93 %/61 % and 93 %/78 % for all patients, 91 %/44 % and 92 %/71 % for the PT patients and 96 %/62 % and 95 %/59 % for the CIT patients, respectively. No significant differences were observed between PT and CIT. Local recurrence was observed in 8 patients (PT: 5, CIT: 3) and 29 (PT: 18, CIT: 11) experienced distant metastases. Acute reactions were acceptable and all patients completed the planned radiotherapy. Regarding late toxicity, grade 3 or greater events were observed in 5 patients (PT: 3, CIT: 2), but no significant difference was observed between PT and CIT.Conclusion. Our single-institution retrospective analysis demonstrated that particle therapy for HNMM achieved good LC, but OS was unsatisfactory. There were no significant differences between PT and CIT in terms of either efficacy or toxicity.