Traditional Chinese Medicine: Balancing the Gut Ecosystem
Traditional Chinese Medicine: Balancing the Gut Ecosystem
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DOI：
10.1002/ptr.2590
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发表时间：
2009-09-01
影响因子：
7.2
通讯作者：
Jia, Wei
中科院分区：
文献类型：
--
作者：
Li, Houkai;Zhou, Mingmei;Jia, Wei
在全球系统生物学的背景下，肠道微生物区系已成为生命科学中感兴趣的话题，其中人类生物系统被视为涉及多种微生物组的内部生态系统的“超级有机体”。我们认为，中药对人体肠道微生物系统的多途径调节，以恢复肠道生态平衡，可能是其在治疗过程中对宿主有效性的很大一部分。一系列研究揭示了肠道菌群与中医药之间的互动关系，涉及两个重要方面：中医药肠道菌群依赖性药物代谢和肠道菌群靶向调节生理状态，这两个方面都突出了肠道菌群参与中医药研究的重要性。版权所有（c）2009约翰威利父子有限公司。
Gut microflora has become a topic of interest in life sciences in the context of global systems biology, in which human biological system is viewed as 'superorganisms' involving an internal ecosystem of diverse microbiome. We conceive that multi-pathway modulations of the human gut microbial system exerted by traditional Chinese medicines (TCMs) to restore the balance of the gut ecology may account for a large portion of their effectiveness in host during treatment. Such a concept is evidenced by series of studies which have revealed an interactive relationship between gut microflora and TCM, involving the two important aspects: gut microflora-dependent drug metabolism in TCM and gut microflora-targeted modulation of physiological conditions, both of which highlight the significance of gut microflora involvement in the future TCM investigation. Copyright (c) 2009 John Wiley & Sons, Ltd.