Extracellular Vesicles in Acute Kidney Injury and Clinical Applications.
Extracellular Vesicles in Acute Kidney Injury and Clinical Applications.
复制标题
细胞外囊泡在急性肾损伤中的作用及临床应用。
DOI：
10.3390/ijms22168913
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发表时间：
2021-08-18
影响因子：
5.6
通讯作者：
Kwon SH
中科院分区：
文献类型：
--
作者：
Oh S;Kwon SH
急性肾损伤（阿基）--由于组织损伤导致肾功能突然丧失并随后进展为慢性肾脏疾病--具有高发病率和死亡率，是一个严重的全球性临床问题。目前的阿基诊断依赖于测量血清肌酐水平和尿量，不能敏感和及时地报告损伤状态。为了解决这些传统诊断工具的缺点，人们开发了几种分子生物标志物来促进阿基的识别和随后的监测。体液中的纳米级膜结合细胞外囊泡（EV）已成为发现此类生物标志物的绝佳来源。除了这种诊断目的外，EV还被广泛用于将治疗性大分子递送到受损的肾细胞以改善阿基。因此，已经进行了许多基于EV的成功的阿基生物标志物发现和治疗应用。在这里，我们回顾了我们对EV如何帮助早期识别和准确监测阿基并用于治疗的理解。我们将进一步讨论目前基于EV的阿基诊断和治疗应用的不足之处，以及未来的创新可以引领我们。
Acute kidney injury (AKI)––the sudden loss of kidney function due to tissue damage and subsequent progression to chronic kidney disease––has high morbidity and mortality rates and is a serious worldwide clinical problem. Current AKI diagnosis, which relies on measuring serum creatinine levels and urine output, cannot sensitively and promptly report on the state of damage. To address the shortcomings of these traditional diagnosis tools, several molecular biomarkers have been developed to facilitate the identification and ensuing monitoring of AKI. Nanosized membrane-bound extracellular vesicles (EVs) in body fluids have emerged as excellent sources for discovering such biomarkers. Besides this diagnostic purpose, EVs are also being extensively exploited to deliver therapeutic macromolecules to damaged kidney cells to ameliorate AKI. Consequently, many successful AKI biomarker findings and therapeutic applications based on EVs have been made. Here, we review our understanding of how EVs can help with the early identification and accurate monitoring of AKI and be used therapeutically. We will further discuss where current EV-based AKI diagnosis and therapeutic applications fall short and where future innovations could lead us.
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影响因子：
46.9
作者：
Alvarez-Erviti, Lydia;Seow, Yiqi;Wood, Matthew J. A.
通讯作者：
Wood, Matthew J. A.
DOI：
10.1152/ajprenal.00184.2011
发表时间：
2012-01-01
影响因子：
4.2
作者：
Bussolati, Benedetta;Moggio, Aldo;Camussi, Giovanni
通讯作者：
Camussi, Giovanni
影响因子：
3.7
作者：
Bruno S;Grange C;Collino F;Deregibus MC;Cantaluppi V;Biancone L;Tetta C;Camussi G
通讯作者：
Camussi G
影响因子：
3.7
作者：
Choi HY;Moon SJ;Ratliff BB;Ahn SH;Jung A;Lee M;Lee S;Lim BJ;Kim BS;Plotkin MD;Ha SK;Park HC
通讯作者：
Park HC
影响因子：
13.6
作者：
Collino, Federica;Bruno, Stefania;Camussi, Giovanni
通讯作者：
Camussi, Giovanni