Monocyte/Macrophage Lineage Cells From Fetal Erythromyeloid Progenitors Orchestrate Bone Remodeling and Repair.
Monocyte/Macrophage Lineage Cells From Fetal Erythromyeloid Progenitors Orchestrate Bone Remodeling and Repair.
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来自胎儿红骨髓祖细胞的单核细胞/巨噬细胞谱系细胞促进骨重建和修复。
DOI：
10.3389/fcell.2021.622035
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发表时间：
2021
影响因子：
5.5
通讯作者：
Alman BA
中科院分区：
文献类型：
--
作者：
Yahara Y;Ma X;Gracia L;Alman BA
三分之一的人口患有骨折，骨折愈合的速度随着年龄的增长而减慢。较慢的修复速度是造成老年人骨折发病率增加的原因。骨愈合通过重叠阶段进行，由单核细胞/巨噬细胞谱系的细胞启动。修复过程以重塑结束。这最后一个阶段由破骨细胞控制，破骨细胞也是单核细胞/巨噬细胞谱系的骨特异性多核细胞。衰老中较慢的愈合速度可以通过来自年轻动物的巨噬细胞来恢复，并且巨噬细胞分泌的蛋白质调节未分化的间充质细胞成为成骨细胞。巨噬细胞可来源于胎儿红骨髓祖细胞或成人造血祖细胞。最近的研究表明，胎儿红骨髓祖细胞负责破骨细胞，破骨细胞形成骨中的造血空间，胎儿破骨细胞前体在出生后驻留在脾脏中，通过血液旅行参与骨折修复。老年和年轻动物巨噬细胞分泌蛋白的差异调节未分化间充质前体细胞向成骨细胞分化的效率。有趣的是，在重塑阶段，破骨细胞可以由来自胎儿和出生后前体群体的单核细胞/巨噬细胞谱系细胞之间的融合形成。来自单细胞RNA测序的数据确定了来自不同前体群体的群体的特异性标记，这一发现可用于未来的研究。本文综述了巨噬细胞和破骨细胞的多样性，并讨论了它们的发育起源和功能的最新发现，为它们在骨稳态和修复中的作用提供了新的见解。
A third of the population sustains a bone fracture, and the pace of fracture healing slows with age. The slower pace of repair is responsible for the increased morbidity in older individuals who sustain a fracture. Bone healing progresses through overlapping phases, initiated by cells of the monocyte/macrophage lineage. The repair process ends with remodeling. This last phase is controlled by osteoclasts, which are bone-specific multinucleated cells also of the monocyte/macrophage lineage. The slower rate of healing in aging can be rejuvenated by macrophages from young animals, and secreted proteins from macrophage regulate undifferentiated mesenchymal cells to become bone-forming osteoblasts. Macrophages can derive from fetal erythromyeloid progenitors or from adult hematopoietic progenitors. Recent studies show that fetal erythromyeloid progenitors are responsible for the osteoclasts that form the space in bone for hematopoiesis and the fetal osteoclast precursors reside in the spleen postnatally, traveling through the blood to participate in fracture repair. Differences in secreted proteins between macrophages from old and young animals regulate the efficiency of osteoblast differentiation from undifferentiated mesenchymal precursor cells. Interestingly, during the remodeling phase osteoclasts can form from the fusion between monocyte/macrophage lineage cells from the fetal and postnatal precursor populations. Data from single cell RNA sequencing identifies specific markers for populations derived from the different precursor populations, a finding that can be used in future studies. Here, we review the diversity of macrophages and osteoclasts, and discuss recent finding about their developmental origin and functions, which provides novel insights into their roles in bone homeostasis and repair.
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Langerhans细胞（LC）增殖介导了新生儿发育，体内平衡和与表皮LC网络的炎症相关扩张。
DOI：
10.1084/jem.20091586
发表时间：
2009-12-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Chorro L;Sarde A;Li M;Woollard KJ;Chambon P;Malissen B;Kissenpfennig A;Barbaroux JB;Groves R;Geissmann F
通讯作者：
Geissmann F
DOI：
10.1084/jem.190.12.1741
发表时间：
1999-12-20
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Arai F;Miyamoto T;Ohneda O;Inada T;Sudo T;Brasel K;Miyata T;Anderson DM;Suda T
通讯作者：
Suda T
DOI：
10.1302/0301-620x.93b6.25596
发表时间：
2011-06-01
影响因子：
--
作者：
Clement, N. D.;Aitken, S. A.;Court-Brown, C. M.
通讯作者：
Court-Brown, C. M.
影响因子：
6.2
作者：
Alexander, Kylie A.;Chang, Ming K.;Pettit, Allison R.
通讯作者：
Pettit, Allison R.
影响因子：
6.2
作者：
Cho, TJ;Gerstenfeld, LC;Einhorn, TA
通讯作者：
Einhorn, TA