Sexual activity, contraception, genital infections, and cervical cancer: support for a sexually transmitted disease hypothesis.
Sexual activity, contraception, genital infections, and cervical cancer: support for a sexually transmitted disease hypothesis.
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性活动、避孕、生殖器感染和宫颈癌：支持性传播疾病假说。
DOI：
10.1093/oxfordjournals.aje.a115331
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发表时间：
1989
影响因子：
5
通讯作者：
Gardner,J
中科院分区：
文献类型：
--
作者：
Slattery,ML;OverallJr,JC;Abbott,TM;French,TK;Robison,LM;Gardner,J
1984年至1987年在犹他州进行了一项病例对照研究，以检查宫颈癌的危险因素。266例组织学证实的原位癌和浸润性鳞状细胞宫颈癌病例与408例对照组进行了访谈。在调整了年龄、教育程度、参加教堂活动和吸烟等因素后，被确定为改变宫颈癌风险的因素包括：（优势比（OR）=8.99为10个或更多的合作伙伴）;目前的配偶有几个性伴侣（10个或更多伴侣的调整OR =8.62）;使用泡沫或果冻作为避孕方法（OR，根据性伴侣数量调整，=0.44）;报告毛滴虫感染（OR，根据性伴侣数量调整，=2.10）;和单纯疱疹病毒2型感染，由2：1中和指数> 100（OR=2.70）。在报告有多个性伴侣的女性中，使用子宫帽（OR=0.67）或避孕套（OR=0.53）具有保护作用。这些数据支持宫颈癌是一种性传播疾病的假设。
A case-control study was conducted in Utah between 1984 and 1987 to examine risk factors for cervical cancer. Interviews were completed with 266 histologically confirmed carcinoma in situ and invasive squamous cell cervical cancer cases who were categorically matched by age to 408 controls. Among the factors identified as altering risk for cervical cancer, after adjustment for age, education, church attendance, and cigarette smoking, were: having numerous sex partners (odds ratio (OR)=8.99 for 10 or more partners); the current mate having several sex partners (adjusted OR for 10 or more partners=8.62); using foam or jelly as a contraceptive method (OR, adjusted for number of sex partners,=0.44); reported Trichomonas infection (OR, adjusted for number of sex partners,=2.10); and herpes simplex virus type 2 infection as determined by 2:1 neutralization index values above 100 (OR=2.70). A protective effect was noted from the use of diaphragms (OR=0.67) or condoms (OR=0.53) in women who reported more than one sex partner. These data support the hypothesis that cervical cancer is a sexually transmitted disease.