Neuropsychological processing associated with recovery from depression after stereotactic subcaudate tractotomy
Neuropsychological processing associated with recovery from depression after stereotactic subcaudate tractotomy
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DOI：
10.1176/appi.ajp.161.10.1913
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发表时间：
2004-10-01
影响因子：
17.7
通讯作者：
Howard, R
中科院分区：
文献类型：
--
作者：
Dalgleish, T;Yiend, J;Howard, R
目的：作者比较了患者进行立体定向尾状核下神经束切断术抑郁症，谁仍然抑郁或恢复抑郁症，以确定治疗mechanism.Method：10抑郁症和8个恢复的精神外科患者，沿着与9个从未抑郁症的主题和9个谁已经从抑郁症与药物治疗恢复，完成了爱荷华州赌博任务，在面对反馈的决策措施。精神外科患者也完成了一般的神经心理学testing.Results：与其他三组相比，在爱荷华州赌博任务上，精神外科患者表现出对负反馈的不敏感性。当一般的神经心理学性能covariated out.Conclusions：这些研究结果表明获得相对不敏感的负面信息作为一个特定的机制介导的抗抑郁作用的立体定向尾状核下神经束切断术。这种不敏感性不是继发于一般神经心理功能的缺陷，也不是抑郁症本身的恢复功能。
Objective: The authors compared patients who underwent stereotactic subcaudate tractotomy for depression, who were still depressed or recovered from depression, to identify therapeutic mechanisms.Method: Ten depressed and eight recovered psychosurgery patients, along with nine never-depressed subjects and nine who had recovered from depression with medication, completed the Iowa Gambling Task, a measure of decision making in the face of feedback. Psychosurgery patients also completed general neuropsychological testing.Results: Recovered psychosurgery patients exhibited insensitivity to negative feedback on the Iowa Gambling Task compared to the other three groups. This difference between the groups remained when general neuropsychological performance was covaried out.Conclusions: These findings suggest acquired relative insensitivity to negative information as a specific mechanism mediating the antidepressant effect of stereotactic subcaudate tractotomy. Such insensitivity is not secondary to deficits in general neuropsychological functioning and is not a function of recovery from depression per se.