Hypertensive heart disease: MR tissue phase mapping reveals altered left ventricular rotation and regional myocardial long-axis velocities
Hypertensive heart disease: MR tissue phase mapping reveals altered left ventricular rotation and regional myocardial long-axis velocities
复制标题
DOI：
10.1007/s00330-012-2613-0
复制
发表时间：
2013-02-01
影响因子：
5.9
通讯作者：
Markl, M.
中科院分区：
文献类型：
--
作者：
Foell, D.;Jung, B.;Markl, M.
本研究应用组织相位图（TPM）技术评价高血压性心脏病患者左室各节段的三维运动速度，对左室肥厚、左室射血分数（EF）正常的患者，采用TPM技术评价左室径向、长轴和旋转运动速度（n = 18，年龄= 53 +/- 12岁）和志愿者（n = 20，年龄= 51 +/- 4岁）。将收缩期和舒张期峰值速度和时间峰值速度映射到16节段LV模型上。在扩展的可视化模型上显示3D心肌运动。通过计算相关系数来研究区域动力学的差异，患者显示舒张功能障碍，表现为所有（除心尖）节段的峰值长轴速度降低（基底节段，P <0.01;两个心室中段，P = 0.02，P = 0.03）。在收缩期，肥厚与长轴速度的异质性行为相关，包括前间隔心尖和心室中部区域的增加（P = 0.001），中下段的减少（P = 0.03）和间隔速度的增加（P < 0.05）。节段性相关分析显示左室基底旋转动力学改变和外侧长轴运动不同步性增加。高血压性心脏病患者表现出收缩期长轴运动、基底旋转和不同步性的改变。需要纵向研究来调查局部室壁运动异常对疾病进展和预后的价值。a Euro cent磁共振组织相位图能够节段性评估3D心肌速度。a Euro cent高血压心脏病患者表现出收缩期长轴运动的新改变。a Euro cent相关分析显示左心室长轴运动异常。轴不同步和旋转改变。欧分MR可能提供有关高血压性心脏病的新的、敏感的诊断标志物。
The aim of this study was the evaluation of left ventricular (LV) segmental 3D velocities in patients with hypertensive heart disease using magnetic resonance (MR) tissue phase mapping (TPM).LV radial, long-axis and rotational myocardial velocities were assessed by TPM in patients with LV hypertrophy and preserved EF (n = 18, age = 53 +/- 12 years) and volunteers (n = 20, age = 51 +/- 4 years). Systolic and diastolic peak and time-to-peak velocities were mapped onto a 16-segment LV model. 3D myocardial motion was displayed on an extended visualisation model. Correlation coefficients were calculated to investigate differences in regional dynamics.Patients revealed diastolic dysfunction as expressed by decreased peak long-axis velocities in all (except apical) segments (basal, P a parts per thousand currency signaEuro parts per thousand 0.01; two midventricular segments, P = 0.02, P = 0.03). During systole, hypertrophy was associated with heterogeneous behaviour for long-axis velocities including an increase in anteroseptal apical and midventricular regions (P = 0.001), a reduction in mid-inferior segments (P = 0.03) and enhanced septal velocities (P < 0.05). Segmental correlation analysis revealed altered dynamics of LV base rotation and increased dyssynchrony of lateral long-axis motion.Patients with hypertensive heart disease demonstrated alterations in systolic long-axis motion, basal rotation and dyssynchrony. Longitudinal studies are needed to investigate the value of regional wall motion abnormalities regarding disease progression and outcome.aEuro cent Magnetic resonance tissue phase mapping enables segmental evaluation of 3D myocardial velocities.aEuro cent Patients with hypertensive heart disease demonstrated new alterations in systolic long-axis motion.aEuro cent Correlation analysis revealed left ventricular long-axis dyssynchrony and an altered rotation.aEuro cent MR may provide new, sensitive diagnostic markers concerning hypertensive heart disease.