Neuropsychological deficits are associated with smoking cessation treatment failure in patients with schizophrenia.
Neuropsychological deficits are associated with smoking cessation treatment failure in patients with schizophrenia.
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DOI：
10.1016/j.schres.2004.01.006
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发表时间：
2004-10-01
影响因子：
4.5
通讯作者：
George, Tony P
中科院分区：
文献类型：
--
作者：
Dolan, Sara L;Sacco, Kristi A;George, Tony P
精神分裂症患者的神经心理表现存在缺陷，其中一些缺陷可以通过吸烟得到改善。这些患者的吸烟率也很高，并且对戒烟干预措施有抵抗力。我们研究了与非精神病对照吸烟者相比，精神分裂症患者在戒烟治疗前存在的神经心理缺陷是否与戒烟治疗失败相关。在精神分裂症和非精神病对照吸烟者的安慰剂对照试验过程中，在药物治疗之前进行神经心理学评估，包括威斯康星州卡片分类测试（WCST）、视觉空间工作记忆（VSWM）任务、斯特鲁普色词测试（SCWT）和连续表现测试（CPT）。在精神分裂症患者 (n=32) 中，VSWM 和 WCST 表现缺陷较大的受试者戒烟的可能性显着降低，但在对照组 (n=40) 中未观察到这种关联。戒烟者和非戒烟者之间的差异不太可能与非典型抗精神病药物治疗或抑郁症状的差异有关。在两组中均未发现 CPT 或 SCWT 基线表现与戒烟状态之间存在关联。这些初步数据表明，在精神分裂症患者中，神经心理缺陷与戒烟治疗失败有关。
Schizophrenics have deficits in neuropsychological performance, some of which are modified by cigarette smoking. These patients also have high rates of smoking and resistance to smoking cessation interventions. We examined whether the presence of neuropsychological deficits prior to smoking cessation treatment was associated with smoking cessation treatment failure in schizophrenic as compared to non-psychiatric control smokers. Neuropsychological assessments were performed prior to treatment with pharmacological agents during the course of placebo-controlled trials in schizophrenic and non-psychiatric control smokers, and included the Wisconsin Card Sorting Test (WCST), a Visuospatial Working Memory (VSWM) task, the Stroop Color Word Test (SCWT) and the Continuous Performance Test (CPT). In schizophrenics (n=32), subjects who had greater deficits in VSWM and WCST performance were significantly less likely to quit smoking, but this association was not observed in controls (n=40). Differences between quitters and non-quitters were not likely related to atypical antipsychotic treatment or differences in depressive symptoms. No associations between baseline performance on CPT or SCWT and quit status were found in either group. These preliminary data suggest that in schizophrenics, neuropsychological deficits are associated with smoking cessation treatment failure.