Airway Obstruction Worsens in Young Adults with Asthma Who Become Obese.
Airway Obstruction Worsens in Young Adults with Asthma Who Become Obese.
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肥胖的年轻哮喘患者气道阻塞会恶化。
DOI：
10.1016/j.jaip.2015.05.009
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
ChildhoodAsthmaManagementProgramResearchGroup
中科院分区：
文献类型：
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作者：
Strunk,RobertC;Colvin,Ryan;Bacharier,LeonardB;Fuhlbrigge,Anne;Forno,Erick;Arbelaez,AnaMaria;Tantisira,KelanG;ChildhoodAsthmaManagementProgramResearchGroup
研究背景很少有研究探讨成年早期肥胖对哮喘病程的影响。我们分析了非肥胖哮喘儿童的肺功能、哮喘损害和风险，比较了成年早期肥胖和非肥胖的儿童。方法我们对771例非肥胖的轻中度哮喘受试者进行了治疗后分析（儿科定义，体重指数[BMI] <第95百分位数）。然后对受试者进行随访，直至20岁或以上。对于年龄在20岁或20岁以上的访视，比较了579名非肥胖受试者和151名肥胖受试者的肺功能测定值（预测百分比）、近期哮喘症状评分和泼尼松暴露（成人定义为BMI ≥ 30 kg/m2）至少1次访视（肥胖时的中位就诊次数= 4，IQR 2-7）。（BMI 23.4 ± 2.6 kg/m2），肥胖者（BMI 31.5 ± 3.8 kg/m2）第一秒用力呼气量（FEV 1）/用力肺活量（FVC）显著降低（P< .0003）和FEV 1（P= .001），FVC（P= .15）在20岁或以上访视期间无差异。BMI每增加一个单位，FEV1%预测值下降0.29（P= 0.0009）。BMI和肺功能之间的关系不受性别或基线BMI的混淆。哮喘损害（症状评分）和风险（泼尼松的使用）没有显着差异2 groups.ConclusionBecoming肥胖在成年早期与增加气道阻塞，没有影响哮喘损害或风险。
BackgroundFew studies have examined how developing obesity in early adulthood affects the course of asthma.ObjectiveWe analyzed lung function and asthma impairment and risk among nonobese children with asthma, comparing those who were obese in young adulthood with those who remained nonobese.MethodsWe carried out thepost hocanalysis of 771 subjects with mild to moderate asthma who were not obese (pediatric definition, body mass index [BMI] < 95th percentile) when enrolled in the Childhood Asthma Management Program at ages 5-12 years. The subjects were then followed to age 20 years or more. For visits at ages 20 years or more, spirometry values as percent predicted and recent asthma symptom scores and prednisone exposure were compared between 579 subjects who were nonobese at all visits and 151 who were obese (adult definition of BMI ≥ 30 kg/m2) on at least 1 visit (median number of visits when obese = 4, IQR 2-7).ResultsCompared with participants who were nonobese (BMI 23.4 ± 2.6 kg/m2), those who became obese (BMI 31.5 ± 3.8 kg/m2) had significant decreases in forced expiratory volume in the first second (FEV1)/forced vital capacity (FVC) (P< .0003) and FEV1(P= .001), without differences in FVC (P= .15) during visits at ages 20 years or more. For each unit increase of BMI, FEV1percent predicted decreased by 0.29 (P= .0009). The relationship between BMI and lung function was not confounded by sex or BMI at baseline. Asthma impairment (symptom scores) and risk (prednisone use) did not differ between the 2 groups.ConclusionBecoming obese in early adulthood was associated with increased airway obstruction, without impact on asthma impairment or risk.