New Cerebello-Cortical Pathway Involved in Higher-Order Oculomotor Control
New Cerebello-Cortical Pathway Involved in Higher-Order Oculomotor Control
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DOI：
10.1007/s12311-020-01108-8
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发表时间：
2020-02-19
期刊：
影响因子：
3.5
通讯作者：
Uchida, Yusuke
中科院分区：
文献类型：
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作者：
Lu, Xiaofeng;Inoue, Ken-ichi;Uchida, Yusuke
小脑和基底神经节在控制与复杂行为相关的随意眼球运动中起着重要作用，但小脑投射如何投射到皮质眼球运动区域却知之甚少。在这里，我们使用狂犬病病毒的逆行transneuronal运输，以确定神经元小脑核，通过丘脑项目的补充视野（SEF）的额皮质的猕猴。狂犬病注射入SEF后，许多神经元的限制区，腹侧的齿状核（DN），尾极的DN，和后间位核（PIN）的标记通过丘脑双突触，而没有神经元标记被发现在前间位核（AIN）。标记神经元的背腹侧分布与运动皮层的DN和PIN神经元不同。在基底神经节中，大量的标记神经元被限制在苍白球（GPi）的内部部分的背内侧部分，因为更多的神经元被标记在GPi的内部部分（GPii）比在GPi的外部部分（GPio）。这是小脑/基底神经节和SEF之间的投射的第一个证据，该投射可以使小脑调节随意眼球运动的认知控制。
The cerebellum and the basal ganglia play an important role in the control of voluntary eye movement associated with complex behavior, but little is known about how cerebellar projections project to cortical eye movement areas. Here we used retrograde transneuronal transport of rabies virus to identify neurons in the cerebellar nuclei that project via the thalamus to supplementary eye field (SEF) of the frontal cortex of macaques. After rabies injections into the SEF, many neurons in the restricted region, the ventral aspects of the dentate nucleus (DN), the caudal pole of the DN, and the posterior interpositus nucleus (PIN) were labeled disynaptically via the thalamus, whereas no neuron labeling was found in the anterior interpositus nucleus (AIN). The distribution of the labeled neurons was dorsoventrally different from that of DN and PIN neurons labeled from the motor cortex. In the basal ganglia, a large number of labeled neurons were confined to the dorsomedial portion of the internal segment of the globus pallidus (GPi) as more neurons were labeled in the inner portion of the GPi (GPii) than in the outer portion of the GPi (GPio). This is the first evidence of a projection between cerebellum/basal ganglia and the SEF that could enable the cerebellum to modulate the cognitive control of voluntary eye movement.