SEVERITY OF CORONARY ATHEROSCLEROSIS CORRELATES WITH THE RESPIRATORY COMPONENT OF HEART-RATE-VARIABILITY
SEVERITY OF CORONARY ATHEROSCLEROSIS CORRELATES WITH THE RESPIRATORY COMPONENT OF HEART-RATE-VARIABILITY
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DOI：
10.1016/0002-8703(91)90664-4
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发表时间：
1991-04-01
影响因子：
4.8
通讯作者：
TAKATA, K
中科院分区：
文献类型：
--
作者：
HAYANO, J;YAMADA, A;TAKATA, K
迷走神经活动减少在冠状动脉疾病中经常被观察到，但这种联系的机制尚不清楚。我们在80名接受冠状动脉造影术的患者中，通过将心率频谱成分与临床和血管造影结果相联系来研究心脏自主神经功能。经年龄和性别调整的呼吸频谱成分的大小与冠状动脉粥样硬化程度呈显著负相关(r=-0.43，p<；0.0001)，与冠状动脉狭窄程度呈不显著负相关(r=-0.30，p=0.0070)。这些关系与既往的心肌梗死和左心功能无关。逐步回归分析显示，呼吸频谱成分对动脉粥样硬化的影响独立于已确定的冠状动脉危险因素(偏R2=9.4%，p=0.002)，但与狭窄无关。我们的结果支持心脏迷走神经活动减少与冠状动脉粥样硬化风险增加相关的假设。
Decreased vagal activity is frequently observed in coronary artery disease, but the mechanism of this association is unknown. We investigated cardiac autonomic function by relating heart rate spectral components to clinical and angiographic findings in 80 patients who were undergoing coronary angiography. The age- and sex-adjusted magnitude of the respiratory spectral component, which is an index of cardiac vagal tone, showed a significant negative correlation with the extent of coronary atheromatosis (r = -0.43, p < 0.0001) and a less significant negative correlation with the severity of coronary stenosis (r = -0.30, p = 0.0070). These relationships were independent of previous myocardial infarction and of left ventricular function. Stepwise regression analysis showed that the respiratory spectral component contributed to atheromatosis independently of established coronary risk factors (partial R2 = 9.4%, p = 0.002), but not to stenosis. Our results support the hypothesis that decreased cardiac vagal activity is associated with an increased risk of coronary atherosclerosis.