Vitamin E deficiency with normal serum vitamin E concentrations in children with chronic cholestasis.
Vitamin E deficiency with normal serum vitamin E concentrations in children with chronic cholestasis.
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慢性胆汁淤积儿童血清维生素 E 浓度正常的维生素 E 缺乏。
DOI：
10.1056/nejm198405103101901
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Balistreri,WF
中科院分区：
文献类型：
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作者：
Sokol,RJ;Heubi,JE;Iannaccone,ST;Bove,KE;Balistreri,WF
我们研究了11例慢性胆汁淤积症合并维生素E缺乏的儿童的血清维生素E水平和血清维生素E与血清脂质水平的比值，这些儿童的维生素E缺乏症除了维生素E的肠道吸收受损外，还通过特征性神经系统体征或腓肠神经组织病理学来定义。其中8名儿童的血清维生素E水平较低，血清维生素E与总脂质和胆固醇的比率也较低。然而，三名患者的血清维生素E水平正常，但血清维生素E与总脂质的比值较低（其中两名患者的维生素E与胆固醇的比值正常）。在四名患者谁不是维生素E缺乏，所有三个值都是normal.We得出结论，维生素E缺乏可能存在于一个孩子与正常的血清维生素E浓度和血清维生素E与总血脂的比值是最可靠的维生素E状态的生化指标在慢性儿童胆汁淤积症。（N Engl J Med 1984; 310：1209-12.）
We studied serum vitamin E levels and the ratio of serum vitamin E to serum lipid levels in 11 children with chronic cholestasis complicated by vitamin E deficiency, as defined by characteristic neurologic signs or sural-nerve histopathology in addition to impaired intestinal absorption of vitamin E. Eight of the children had low levels of serum vitamin E, as well as low ratios of serum vitamin E to total lipids and to cholesterol. However, three patients had normal serum vitamin E levels but low ratios of serum vitamin E to total lipids (two of the three had normal ratios of vitamin E to cholesterol). In four patients who were not vitamin E–deficient, all three values were normal.We conclude that vitamin E deficiency may exist in a child with a normal serum vitamin E concentration and that the ratio of serum vitamin E to total serum lipids is the most reliable biochemical index of vitamin E status during chronic childhood cholestasis. (N Engl J Med 1984; 310: 1209–12.)