INHIBITION OF METHAMPHETAMINE SENSITIZATION BY POST-METHAMPHETAMINE TREATMENT WITH SCH-23390 OR HALOPERIDOL
INHIBITION OF METHAMPHETAMINE SENSITIZATION BY POST-METHAMPHETAMINE TREATMENT WITH SCH-23390 OR HALOPERIDOL
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DOI：
10.1007/bf02246051
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发表时间：
1995-05-01
影响因子：
3.4
通讯作者：
KURIBARA, H
中科院分区：
文献类型：
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作者：
KURIBARA, H
甲基苯丙胺（2 mg/kg SC）增加小鼠中的amalgamin约3 h，在给药后约40 min达到峰值效应，重复给药可诱导致敏作用，SCH 23390（0.03 mg/kg SC）和氟哌啶醇（0.4 mg/kg SC）、多巴胺D-1和D-2受体拮抗剂，完全抑制甲基苯丙胺的急性兴奋作用，而且当重复甲基苯丙胺与这些药物中的任一种重复组合时，也完全抑制其致敏作用。此外，每次甲基苯丙胺给药后2-5 h给予SCH 23390或1-5 h给予氟哌啶醇可显著拮抗甲基苯丙胺致敏作用。最大的抑制作用中观察到的时间表3小时后甲基苯丙胺治疗两种药物。然而.在甲基苯丙胺后0.5 h、6 h和34 h给予SCH 23390或氟哌啶醇则无这种抑制作用。每次生理盐水给药后接受SCH 23390或氟哌啶醇给药的小鼠（甲基安非他明的对照给药）没有显示出对甲基安非他明的敏感性的显著变化。这些结果表明甲基安非他明对多巴胺D-1和D-2受体都有作用，即使在其急性刺激作用停止后也有几个小时，并且这种作用涉及对甲基苯丙胺对小鼠中的amphetamine的刺激作用的致敏诱导。
Methamphetamine (2 mg/kg SC) increased ambulation in mice for about 3 h, with a peak effect at around 40 min after the administration, and its repeated administration induced sensitization, Both SCH 23390 (0.03 mg/kg SC) and haloperidol (0.4 mg/kg SC), dopamine D-1 and D-2 receptor antagonists, respectively, completely inhibited not only the acute stimulant effect of methamphetamine but also its sensitization when repeated methamphetamine was repeatedly combined with either of these drugs. Moreover, treatment with SCH 23390 2-5 h or haloperidol 1-5 h after each methamphetamine administration significantly antagonized methamphetamine sensitization. The maximal inhibitory effect was observed in the schedules of 3-h post-methamphetamine treatment for both drugs. However. treatments with SCH 23390 or haloperidol at 0.5 h, 6 h and 34 h after methamphetamine had no such inhibitory effect. The mice treated with SCH 23390 or haloperidol after each saline administration (the control administration for methamphetamine) did not show significant change in the sensitivity to methamphetamine, These results suggest that methamphetamine has an effect on both dopamine D-1 and D-2 receptors for several hours even after cessation of its acute stimulant effect, and that such an effect is involved in the induction of sensitization to the stimulant effect of methamphetamine on ambulation in mice.