Exercise-induced lipid mobilization in subcutaneous adipose tissue is mainly related to natriuretic peptides in overweight men
Exercise-induced lipid mobilization in subcutaneous adipose tissue is mainly related to natriuretic peptides in overweight men
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DOI：
10.1152/ajpendo.90227.2008
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发表时间：
2008-08-01
影响因子：
5.1
通讯作者：
Berlan, Michel
中科院分区：
文献类型：
--
作者：
Moro, Cedric;Pillard, Fabien;Berlan, Michel
比较了超重和瘦人中交感神经系统和利钠肽在运动诱导的脂质动员控制中的作用。在运动过程中使用局部微透析测定脂质动员。受试者在安慰剂组或口服特他洛尔（一种β-肾上腺素能受体（AR）拮抗剂）后，以最大耗氧量的60%进行35分钟的运动。在安慰剂组中，运动增加了两组的透析液甘油浓度（DGC）。酚妥拉明（α-AR拮抗剂）增强超重受试者的运动诱导的脂解，但在瘦受试者中没有; α 2-抗脂解作用仅在超重男性中起作用。运动时，无论使用哪种探头，服用特他洛尔后，两组DGC的增加相似。与安慰剂下的对照探针相比，用β-AR阻断剂治疗的瘦男性的脂解减少，但超重男性的脂解没有减少。特他洛尔降低血浆非酯化脂肪酸和胰岛素浓度在两组在休息。在安慰剂或特他洛尔下，两组运动诱导的血浆非酯化脂肪酸、甘油和胰岛素浓度变化相似。运动促进了特他洛尔给药后儿茶酚胺和ANP血浆水平的较高增加。总之，我们研究的主要发现是，在超重男性中，除了增加α（2）-抗脂解作用外，在β-受体阻滞剂下运动期间持续存在的皮下脂肪组织中的脂质动员不依赖于儿茶酚胺作用。相关性研究结果的基础上，它似乎是相关的伴随运动引起的血浆心钠素升高时，运动进行下特他洛尔摄入量和血浆胰岛素减少。
Involvement of sympathetic nervous system and natriuretic peptides in the control of exercise-induced lipid mobilization was compared in overweight and lean men. Lipid mobilization was determined using local microdialysis during exercise. Subjects performed 35-min exercise bouts at 60% of their maximal oxygen consumption under placebo or after oral tertatolol [a beta-adrenergic receptor (AR) antagonist]. Under placebo, exercise increased dialysate glycerol concentration (DGC) in both groups. Phentolamine (alpha-AR antagonist) potentiated exercise-induced lipolysis in overweight but not in lean subjects; the alpha(2)-antilipolytic effect was only functional in overweight men. After tertatolol administration, the DGC increased similarly during exercise no matter which was used probe in both groups. Compared with the control probe under placebo, lipolysis was reduced in lean but not in overweight men treated with the beta-AR blocker. Tertatolol reduced plasma nonesterified fatty acids and insulin concentration in both groups at rest. Under placebo or tertatolol, the exercise-induced changes in plasma nonesterified fatty acids, glycerol, and insulin concentrations were similar in both groups. Exercise promoted a higher increase in catecholamine and ANP plasma levels after tertatolol administration. In conclusion, the major finding of our study is that in overweight men, in addition to an increased alpha(2)-antilipolytic effect, the lipid mobilization in subcutaneous adipose tissue that persists during exercise under beta-blockade is not dependent on catecholamine action. On the basis of correlation findings, it seems to be related to a concomitant exercise-induced rise in plasma ANP when exercise is performed under tertatolol intake and a decrease in plasma insulin.