Central and peripheral blood pressures in relation to plasma advanced glycation end products in a Chinese population
Central and peripheral blood pressures in relation to plasma advanced glycation end products in a Chinese population
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中国人群中心血压和外周血压与血浆晚期糖基化终末产物的关系
DOI：
10.1038/jhh.2015.60
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发表时间：
2016-07-01
影响因子：
2.7
通讯作者：
Wang, J-G
中科院分区：
文献类型：
--
作者：
Huang, Q-F;Sheng, C-S;Wang, J-G
我们研究了中国人群血浆AGE（晚期糖基化终产物）浓度与中心和外周血压以及中心-肱动脉血压放大的关系。研究对象来自上海郊区一个新建的居住区。使用SphygmoCor系统，我们记录了桡动脉波形和推导出的主动脉波形的广义传递函数和中心收缩压和脉搏压的肱动脉血压测量装置校准。中心-肱动脉压放大率表示为中心-肱动脉收缩压差和脉压差及其比值。用酶联免疫吸附法测定血浆AGE浓度，并进行数学转换进行统计学分析。1051名参与者（年龄，55.1±13.1岁）包括663名女性。校正性别、年龄和其他混杂因素后，血浆AGE浓度与中心血压相关，但与外周血压和某些压力放大指数无关。事实上，血浆AGE浓度每增加10倍，中心收缩压升高2.94 mm Hg（P= 0.04），中心-肱动脉脉压比降低2.39%（P= 0.03）。在进一步的亚组分析中，这种关联在高胆固醇血症中更为突出（+ 8.11 mm Hg，P= 0.008）的中心收缩压和存在超重和肥胖（− 4.89%，P= 0.009）、糖尿病和前驱糖尿病（− 6.26%，P= 0.10）或目前吸烟（− 6.68%，P= 0.045）的中心-肱动脉脉压比。总之，血浆AGE浓度与中心收缩压和脉压放大独立相关，特别是在存在几种可改变的心血管危险因素的情况下。
We investigated the association of plasma AGE (advanced glycation end product) concentration with central and peripheral blood pressures and central-to-brachial blood pressure amplification in a Chinese population. The study subjects were from a newly established residential area in the suburb of Shanghai. Using the SphygmoCor system, we recorded radial arterial waveforms and derived aortic waveforms by a generalized transfer function and central systolic and pulse pressure by calibration for brachial blood pressure measured with an oscillometric device. The central-to-brachial pressure amplification was expressed as the central-to-brachial systolic blood pressure difference and pulse pressure difference and ratio. Plasma AGE concentration was measured by the enzyme-linked immunosorbent assay method and logarithmically transformed for statistical analysis. The 1051 participants (age, 55.1±13.1 years) included 663 women. After adjustment for sex, age and other confounding factors, plasma AGE concentration was associated with central but not peripheral blood pressures and with some of the pressure amplification indexes. Indeed, each 10-fold increase in plasma AGE concentration was associated with 2.94 mm Hg (P= 0.04) higher central systolic blood pressure and 2.39% lower central-to-brachial pulse pressure ratio (P= 0.03). In further subgroup analyses, the association was more prominent in the presence of hypercholesterolemia (+ 8.11 mm Hg, P= 0.008) for central systolic blood pressure and in the presence of overweight and obesity (− 4.89%, P= 0.009), diabetes and prediabetes (− 6.26%, P= 0.10) or current smoking (− 6.68%, P= 0.045) for central-to-brachial pulse pressure ratio. In conclusion, plasma AGE concentration is independently associated with central systolic blood pressure and pulse pressure amplification, especially in the presence of several modifiable cardiovascular risk factors.