Genetic/Familial High-Risk Assessment: Colorectal, Version 2.2019 Featured Updates to the NCCN Guidelines
Genetic/Familial High-Risk Assessment: Colorectal, Version 2.2019 Featured Updates to the NCCN Guidelines
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DOI：
10.6004/jnccn.2019.0044
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发表时间：
2019-09-01
影响因子：
13.4
通讯作者：
Ogba, Ndiya
中科院分区：
文献类型：
--
作者：
Gupta, Samir;Provenzale, Dawn;Ogba, Ndiya
识别具有遗传综合征的个体可以改善癌症监测，降低风险和优化管理。制定评估标准，可以查明致病性遗传变异携带者。NCCN遗传/家族性高风险评估指南：结直肠为高风险结直肠癌综合征患者的评估和管理提供了建议。这些NCCN指南见解侧重于Lynch综合征的评估标准和在遗传性结直肠癌综合征评估中使用多基因检测的考虑因素。
Identifying individuals with hereditary syndromes allows for improved cancer surveillance, risk reduction, and optimized management. Establishing criteria for assessment allows for the identification of individuals who are carriers of pathogenic genetic variants. The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Colorectal provide recommendations for the assessment and management of patients with high-risk colorectal cancer syndromes. These NCCN Guidelines Insights focus on criteria for the evaluation of Lynch syndrome and considerations for use of multigene testing in the assessment of hereditary colorectal cancer syndromes.