Obesity and gastric cancer
Obesity and gastric cancer
复制标题
肥胖与胃癌
DOI：
10.2741/4059
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发表时间：
2012-06-01
影响因子：
3.1
通讯作者：
Qiao, Liang
中科院分区：
文献类型：
--
作者：
Li, Qiang;Zhang, Jun;Qiao, Liang
肥胖是一个重要的全球性公共卫生问题。它增加了许多慢性疾病的风险，如糖尿病和心血管疾病。同时，肥胖是包括胃癌在内的几种癌症的主要危险因素。肥胖与胃癌的可能联系机制包括肥胖相关的胃食管反流、胰岛素抵抗、脂联素、瘦素、生长激素释放肽水平的改变以及胰岛素样生长因子（IGF）血液水平的异常升高。幽门螺杆菌（H.幽门螺杆菌）感染是公认的消化性溃疡和胃癌的危险因素。最近的研究表明H. pylori感染，为肥胖人群胃癌发病率增高提供了又一线索。如果这种联系能够在动物模型和大量患者中得到证实，那么就可以根除H。幽门螺杆菌的感染以及改变肥胖者的生活方式可能有助于预防日益肥胖人群中胃癌的发生。
Obesity is an important public health problem worldwide. It increases the risk of many chronic diseases such as diabetes and cardiovascular diseases. Meanwhile, obesity is a major risk factor for several types of cancer including gastric cancer. Possible mechanisms linking obesity with gastric cancer may include obesity associated gastro-oesophageal reflux, insulin resistance, altered levels of adiponectin, leptin, ghrelin, and an abnormally increased blood level of insulin-like growth factor (IGF). Helicobacter pylori (H. pylori) infection is a well-recognized risk factor for peptic ulcer and gastric cancer. Recent studies have revealed an increased prevalence of H. pylori infection in obese patients, providing another clue for the increased incidence of gastric cancer in obese population. If this connection can be confirmed in animal models and a large cohort of patients, then eradicating H. pylori together with life style modification in obese individuals may help prevent the development of gastric cancer in the increasingly obese population.