Do the two transcription factors form a positive feedback amplifier circuit in their common fight against pathogens?
Do the two transcription factors form a positive feedback amplifier circuit in their common fight against pathogens?
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这两种转录因子在共同对抗病原体时是否形成正反馈放大电路？
DOI：
10.1111/imcb.12198
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发表时间：
2018
影响因子：
4
通讯作者：
中科院分区：
文献类型：
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作者：
干扰素调节因子1（IRF1）和信号转导和转录激活因子1（STAT1）都是诱导干扰素（IFN）驱动基因亚组所必需的。然而，目前还不清楚这两种转录因子如何相互作用以上调免疫调节基因的表达。在这期《免疫学与细胞生物学》杂志上发表的一篇有趣的文章中，
Interferon regulatory factor 1 (IRF1) and signal transducer and activator of transcription 1 (STAT1) are both required for the induction of a subgroup of interferon (IFN)-driven genes. However, it is unknown how the two transcription factors interact to upregulate the expression of immune-regulated genes. In an interesting article published in this issue of Immunology & Cell Biology,