The impact of body weight gain on nonalcoholic fatty liver disease and metabolic syndrome during earlier and later adulthood
The impact of body weight gain on nonalcoholic fatty liver disease and metabolic syndrome during earlier and later adulthood
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DOI：
10.1016/j.diabres.2016.04.047
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发表时间：
2016-06-01
影响因子：
5.1
通讯作者：
Sun, Changhao
中科院分区：
文献类型：
--
作者：
Du, Shanshan;Wang, Cheng;Sun, Changhao
目的：体重增加增加了代谢紊乱的风险，并且成年早期和晚期有不同的代谢变化。然而，它对非酒精性脂肪肝病（NAFLD）的影响尚不确定。本研究的目的是评估体重增加在整个成年期、早期（25-40岁）和晚期（40岁以上）期间对NAFLD和代谢综合征（MetS）的影响。方法：选择1119名受试者计算体重（Delta BW）、体重指数（BMI）（Delta BMI）和每年体重（Delta BW/y）的变化，以多变量回归分析其对NAFLD和MetS的影响结果：整个成年期的Delta BMI、Delta BW和Delta BW/y均与NAFLD和MetS呈正相关。与成年后期相比，成年早期体重增加与 NAFLD 的相关性更强。在 NAFLD 中，成年早期 Delta BMI（第三等分）、Delta BW 和 Delta BW/y 的 OR 分别为 3.86 (2.25, 6.57)、1.05 (1.02, 1.09) 和 2.05 (1.29, 3.24)，而成年早期则为 1.47 (1.09, 2.02)、1.02 (1.00, 1.06) 和 1.04 (.99, 1.13) 超过 40 岁。胰岛素和 HOMA-IR 是 Delta BMI 与 NAFLD 相关的重要中间体。成年早期的 Delta BMI 比成年后期的胰岛素和胰岛素抵抗 (IR) 更高。结论：成年时期的体重增加与 NAFLD 和 MetS 呈正相关，并且这种关联在成年早期比成年后期更强。胰岛素和 IR 是促成这种关联的重要调节因素。 (C) 2016 Elsevier Ireland Ltd. 保留所有权利。
Aim: Body weight gain adds risk for metabolic disorders and there are different metabolic changes in earlier and later adulthood. However, its impact on non-alcoholic fatty liver disease (NAFLD) was indeterminate. The aim of current study was to evaluate the impact of body weight gain on NAFLD and metabolic syndrome (MetS) during overall, earlier (25-40 y) and later (over 40 y) adulthood.Methods: 1119 subjects were selected to calculate changes in body weight (Delta BW), body mass index (BMI) (Delta BMI) and bodyweight per year (Delta BW/y) to analysis their impact on NAFLD and MetS in multi-variable regression models, and explored the potential mediators that associated Delta BMI with NAFLD by mediation analysis.Results: Delta BMI, Delta BW and Delta BW/y in whole adulthood were all positively associated with NAFLD and MetS. Body weight gain during earlier adulthood was more strongly associated with NAFLD than those during later adulthood. In NAFLD, the ORs of Delta BMI (third trisection), Delta BW and Delta BW/y were 3.86 (2.25, 6.57), 1.05 (1.02, 1.09) and 2.05 (1.29, 3.24) during earlier adulthood, and 1.47 (1.09, 2.02), 1.02 (1.00, 1.06), and 1.04 (. 99, 1.13) over 40 y. Insulin and HOMA-IR were important intermediates that associated Delta BMI with NAFLD. Delta BMI in earlier adulthood increased higher insulin and insulin resistance (IR) than later adulthood.Conclusions: Body weight gain in adulthood was positively associated with NAFLD and MetS, and the association was stronger in earlier than later adulthood. Insulin and IR were important mediators that contributed to the association. (C) 2016 Elsevier Ireland Ltd. All rights reserved.