Visual Population Receptive Fields in People with Schizophrenia Have Reduced Inhibitory Surrounds.
Visual Population Receptive Fields in People with Schizophrenia Have Reduced Inhibitory Surrounds.
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DOI：
10.1523/jneurosci.3620-15.2016
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发表时间：
2017-02-08
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影响因子：
--
通讯作者：
Dakin SC
中科院分区：
文献类型：
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作者：
Anderson EJ;Tibber MS;Schwarzkopf DS;Shergill SS;Fernandez-Egea E;Rees G;Dakin SC
精神分裂症（SZ）患者在一系列视觉任务中经历异常的视觉感知，这与异常的突触传递和皮质兴奋与抑制之间的不平衡有关。然而，视觉皮层神经元的基础架构的差异，这可能解释这些视觉异常，尚未在体内报告。在这里，我们探讨了这些赤字的神经基础，使用功能磁共振成像和群体感受野（pRF）映射来推断SZ患者视觉反应神经元的特性。我们采用高斯差分模型来捕获pRF的中心-环绕构型，提供关于pRF抑制性环绕的空间尺度的关键信息。我们的分析表明，SZ与早期视网膜视皮层的pRF大小减少，以及V1，V2和V4抑制周围的大小和深度减少有关。我们考虑如何减少抑制可能会解释不同范围的视觉缺陷报道在深圳。精神分裂症（SZ）患者在一系列视觉任务中经历异常感知，这与异常突触传递和皮质兴奋/抑制之间的不平衡有关。然而，视觉皮层神经元的功能结构的相关差异尚未在体内报告。我们使用fMRI和群体感受野（pRF）映射来证明SZ患者视觉皮层的细粒度功能结构与未受影响的对照组不同。SZ与早期视网膜视皮层中pRF大小的减少有关，这主要是由于抑制性周围减少。皮质兴奋和抑制之间的不平衡可以驱动这样的变化，在中心环绕的pRF配置，并最终解释的范围内的视觉缺陷的SZ经历。
People with schizophrenia (SZ) experience abnormal visual perception on a range of visual tasks, which have been linked to abnormal synaptic transmission and an imbalance between cortical excitation and inhibition. However, differences in the underlying architecture of visual cortex neurons, which might explain these visual anomalies, have yet to be reported in vivo. Here, we probed the neural basis of these deficits using fMRI and population receptive field (pRF) mapping to infer properties of visually responsive neurons in people with SZ. We employed a difference-of-Gaussian model to capture the center-surround configuration of the pRF, providing critical information about the spatial scale of the pRFs inhibitory surround. Our analysis reveals that SZ is associated with reduced pRF size in early retinotopic visual cortex, as well as a reduction in size and depth of the inhibitory surround in V1, V2, and V4. We consider how reduced inhibition might explain the diverse range of visual deficits reported in SZ. SIGNIFICANCE STATEMENT People with schizophrenia (SZ) experience abnormal perception on a range of visual tasks, which has been linked to abnormal synaptic transmission and an imbalance between cortical excitation/inhibition. However, associated differences in the functional architecture of visual cortex neurons have yet to be reported in vivo. We used fMRI and population receptive field (pRF) mapping to demonstrate that the fine-grained functional architecture of visual cortex in people with SZ differs from unaffected controls. SZ is associated with reduced pRF size in early retinotopic visual cortex largely due to reduced inhibitory surrounds. An imbalance between cortical excitation and inhibition could drive such a change in the center-surround pRF configuration and ultimately explain the range of visual deficits experienced in SZ.