ENDOTHELIN-1 INDUCES POTENT CONSTRICTION OF LYMPHATIC VESSELS INSITU
ENDOTHELIN-1 INDUCES POTENT CONSTRICTION OF LYMPHATIC VESSELS INSITU
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DOI：
10.1016/0014-2999(89)90135-0
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发表时间：
1989-10-24
影响因子：
5
通讯作者：
GARCIALEME, J
中科院分区：
文献类型：
--
作者：
FORTES, ZB;SCIVOLETTO, R;GARCIALEME, J
借助高分辨率电视显微镜检查外置大鼠肠系膜中的淋巴管、小动脉和小静脉对内皮素-1、加压素和去甲肾上腺素的反应。在摩尔基础上，内皮素-1 比加压素更有效地收缩三种类型的血管。去甲肾上腺素可以收缩微血管，但对淋巴管没有作用。乙酰胆碱、硝普钠和异丙肾上腺素不能有效阻断淋巴管对内皮素-1 和加压素的收缩反应。然而，在相同浓度下，乙酰胆碱和硝普钠会拮抗小动脉和小静脉对内皮素-1和去甲肾上腺素的反应，而血管微血管对加压素的反应则不受影响。异丙肾上腺素在能够阻断小动脉和小静脉对去甲肾上腺素反应的剂量下，不会干扰内皮素-1和加压素在这些血管上引起的收缩。提示内皮素-1除了具有血管收缩活性外，还可能在淋巴收缩力的调节中发挥作用。
The response of lymph vessels, arterioles and venules in the exteriorized rat mesentery to endothelin-1, vasopressin and norepinephrine was examined with the aid of high-resolution television microscopy. On a molar basis, endothelin-1 was more potent than vasopressin to contract the three types of vessels. Norepinephrine, which could constrict blood microvessels, did not act on lymph vessels. Acetylcholine, sodium-nitroprusside and isoproterenol were ineffective to block the constrictive responses of lymph vessels to endothelin-1 and vasopressin. At the same concentrations, however, acetylcholine and sodium-nitroprusside antagonized the responses of arterioles and venules to endothelin-1 and norepinephrine, whereas the responses of blood microvessels to vasopressin remained unaffected. Isoproterenol, at doses capable of blocking the response of the arterioles and venules to norepinephrine, did not interfere with the constriction induced by endothelin-1 and vasopressin on these vessels. It is suggested that endothelin-1 might play a role in the regulation of lymphatic contractility apart from its vasconstrictor activity on blood vessels.