GRIN lens rod based probe for endoscopic spectral domain optical coherence tomography with fast dynamic focus tracking
GRIN lens rod based probe for endoscopic spectral domain optical coherence tomography with fast dynamic focus tracking
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DOI：
10.1364/oe.14.003238
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发表时间：
2006-04-17
期刊：
影响因子：
3.8
通讯作者：
Brenner, M
中科院分区：
文献类型：
--
作者：
Xie, TQ;Guo, SG;Brenner, M
本文提出了一种基于梯度指数透镜棒的内窥镜光谱域光学相干断层扫描（OCT）探头，具有动态焦点跟踪功能。目前的内镜OCT系统有一个固定的焦平面或工作距离。相比之下，该内窥镜OCT探头的焦点可以在高速（500 mm/s）下动态调整，而无需改变参考臂长，从而获得高质量的OCT图像，用于接触式或非接触式组织应用，或用于探头难以进入的区域。探头的动态聚焦范围为0 ~ 7.5 mm，无需移动探头本身。成像深度为2.8 mm，横向扫描范围可达2.7 mm或4.5 mm（由不同GRIN透镜杆直径决定）。使用该系统可以在与GRIN透镜表面对应的组织区域上进行三维成像。实验结果表明，基于GRIN透镜棒的OCT系统可以实现高质量的非接触式活体成像。这种刚性OCT探头是固体的，可以安全地进入内部器官，以每秒8帧的成像速度进行正面或侧面成像，所有活动部件都靠近GRIN透镜，并且在生物研究和临床应用中用于极其紧凑的OCT内窥镜的体内成像具有很大的潜力。(c) 2006年美国光学学会。
In this manuscript, a GRIN (gradient index) lens rod based probe for endoscopic spectral domain optical coherence tomography (OCT) with dynamic focus tracking is presented. Current endoscopic OCT systems have a fixed focal plane or working distance. In contrast, the focus of this endoscopic OCT probe can dynamically be adjusted at a high speed (500 mm/s) without changing reference arm length to obtain high quality OCT images for contact or non-contact tissue applications, or for areas of difficult access for probes. The dynamic focusing range of the probe can be from 0 to 7.5 mm without moving the probe itself. The imaging depth is 2.8 mm and the lateral scanning range is up to 2.7 mm or 4.5 mm (determined by the diameter of different GRIN lens rods). Three dimensional imaging can be performed using this system over an area of tissue corresponding to the GRIN lens surface. The experimental results demonstrate that this GRIN lens rod based OCT system can perform a high quality non-contact in vivo imaging. This rigid OCT probe is solid and can be adapted to safely access internal organs, to perform front or side view imaging with an imaging speed of 8 frames per second, with all moving parts proximal to the GRIN lens, and has great potential for use in extremely compact OCT endoscopes for in vivo imaging in both biological research and clinical applications. (c) 2006 Optical Society of America.