Direct Evidence for Domain-Sensitive Functional Subregions in Human Entorhinal Cortex
Direct Evidence for Domain-Sensitive Functional Subregions in Human Entorhinal Cortex
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DOI：
10.1523/jneurosci.5126-11.2012
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发表时间：
2012-04-04
影响因子：
5.3
通讯作者：
Peters, Jan
中科院分区：
文献类型：
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作者：
Schultz, Heidrun;Sommer, Tobias;Peters, Jan
众所周知，内侧颞叶（MTL）在记忆过程中发挥着至关重要的作用。动物研究的解剖学发现表明，部分分离的 MTL 通路在海马体中汇聚，后流包括海马旁和内侧内嗅皮层，前流包括鼻周和外侧内嗅皮层。这些流可以分别对空间和非空间信息进行操作。在人类中，海马旁皮层和鼻周皮层之间存在这种功能性分离。来自啮齿动物和非人类灵长类动物的数据表明，内侧和外侧内嗅皮层之间存在类似的分离，它们与海马旁皮层和鼻周皮层相互连接，但缺乏人类内嗅皮层内功能分区的证据。我们使用高分辨率功能磁共振成像和改进的空间标准化来解决这个问题。志愿者（n = 28）执行了工作记忆范式，涉及在分散注意力后检索空间（场景）和非空间（面孔）信息。 MTL 子电路之间出现了明显的分离。鼻周-外侧内嗅通路更多地参与分心后面部的检索，而海马旁-内侧内嗅通路更多地参与分心后场景的检索。海马体后部的一个簇显示出在分散注意力后面部检索的失活。因此，我们的数据为人类内嗅皮层内的功能专业化提供了直接证据，从而有力地支持了强调部分隔离并行处理流重要性的 MTL 模型。
The medial temporal lobes (MTL) are known to play a crucial role in memory processes. Anatomical findings from animal studies suggest partially segregated MTL pathways converge in the hippocampus, with a posterior stream including parahippocampal and medial lateral entorhinal cortex and an anterior stream including perirhinal and lateral entorhinal cortex. These streams may operate on spatial and nonspatial information, respectively. In humans, such a functional dissociation has been suggested between parahippocampal and perirhinal cortex. Data from rodents and nonhuman primates suggest a similar dissociation between medial and lateral entorhinal cortex, which are reciprocally connected to parahippocampal and perirhinal cortex, but evidence for functional subregions within entorhinal cortex in humans is lacking. We addressed this issue using high-resolution fMRI with improved spatial normalization. Volunteers (n = 28) performed a working memory paradigm involving the retrieval of spatial (scenes) and nonspatial (faces) information after distraction. A clear dissociation between MTL subcircuits emerged. A perirhinal-lateral entorhinal pathway was more involved in the retrieval of faces after distraction, whereas a parahippocampal-medial entorhinal pathway was more involved in the retrieval of scenes after distraction. A cluster in posterior hippocampus showed a deactivation for the retrieval of faces after distraction. Our data thus provide direct evidence for a functional specialization within human entorhinal cortex and thereby strongly support MTL models that emphasize the importance of partially segregated parallel processing streams.