Serological classification of Neisseria gonorrhoeae with use of monoclonal antibodies to gonococcal outer membrane protein I.
Serological classification of Neisseria gonorrhoeae with use of monoclonal antibodies to gonococcal outer membrane protein I.
复制标题
使用淋球菌外膜蛋白 I 的单克隆抗体对淋病奈瑟菌进行血清学分类。
DOI：
10.1093/infdis/150.1.44
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Sandström,EG
中科院分区：
文献类型：
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作者：
Knapp,JS;Tam,MR;Nowinski,RC;Holmes,KK;Sandström,EG
在淋病奈瑟菌上鉴定出能够将淋病球菌区分为大量不同类别的菌株特异性标记，有助于分析淋病传播模式和应用淋病控制措施。用12种淋球菌外膜蛋白IA （PrIA）和IB （PrIB）单克隆抗体对1433株淋球菌进行了血清学分类。鉴定出18个PrIA和28个PrIB血清型，并提出了命名法。淋球菌菌株通过缺陷分型进一步分类。辅助型和血清型将1433株分离株分为107个独特的辅助型/血清型。根据异型和血清型进行双重分类可用于识别流行病学相关的淋球菌感染，以检验控制淋病的创新、重点措施的有效性。
Identification of strain-specific markers onNeisseria gonorrhoeaethat are capable of differentiating gonococci into a large number of distinct classes could facilitate analysis of patterns of gonorrhea transmission and application of gonorrhea control measures. A panel of 12 monoclonal antibodies to gonococcal outer membrane protein IA (PrIA) and IB (PrIB) was used to classify 1,433 strains serologically in a worldwide survey. Eighteen PrIA and 28 PrIB serovars were identified, and a nomenclature is proposed. Gonococcal strains were classified further by auxotyping. Auxotyping and serotyping served to classify the 1,433 isolates into 107 unique auxotype/serovar classes. Dual classification by auxotype and serovar can be used to identify epidemiologically related gonococcal infections in order to test the effectiveness of innovative, focused measures to control gonorrhea.