High-fat diet-induced hyperglycemia and obesity in mice: Differential effects of dietary oils
High-fat diet-induced hyperglycemia and obesity in mice: Differential effects of dietary oils
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DOI：
10.1016/s0026-0495(96)90185-7
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发表时间：
1996-12-01
影响因子：
9.8
通讯作者：
Ezaki, O
中科院分区：
文献类型：
--
作者：
Ikemoto, S;Takahashi, M;Ezaki, O
喂食高脂肪食物的老鼠会患上高血糖症和肥胖症。以非胰岛素依赖型糖尿病（NIDDM）模型小鼠为研究对象，研究了7种不同膳食油对糖代谢的影响：棕榈油，其主要含有45%棕榈酸（16:0）和40%油酸（18:1）；猪油，24%棕榈酸和44%油酸；菜籽油，59%油酸和20%亚油酸（18:2）；大豆油，24%油酸，54%亚油酸；红花油，76%亚油酸；紫苏油，58%或亚麻酸；金枪鱼鱼油含有7%的二十碳五烯酸和23%的二十二碳六烯酸。C57BL/6J小鼠给予高脂肪饮食（占总热量的60%）19周（每组n = 6 ~ 11）。饲喂19周后，饲粮诱导体重的大小顺序为：大豆bbb大于等于猪油大于等于油菜籽大于等于红花大于等于紫苏大于等于鱼油。葡萄糖负荷后30分钟葡萄糖水平最高的是红花油（一致为21.5 mmol/L），中等的是菜籽油、大豆油和猪油（一致为17.6 mmol/L），温和的是紫苏、鱼和棕榈油（一致为13.8 mmol/L），最低的是高碳水化合物餐（一致为10.4 mmol/L）。只有棕榈油喂养的小鼠出现空腹高胰岛素血症（P < 0.001）。通过逐步多元回归分析，选择体重（或白色脂肪组织[WAT]重量）和亚油酸摄入量（或n-3/n-6比）作为影响糖耐量的自变量。单因素分析表明，亚油酸摄入量与血糖水平呈正相关（r = 0.83, P = 0.02），与肥胖无关（r = 0.46, P = 0.30）。这些数据表明：(1)空腹血胰岛素水平因脂肪亚型而异，棕榈油喂养的小鼠空腹血胰岛素水平较高，这可能解释了它们较好的血糖控制，而不考虑它们是否明显肥胖；(2)鱼油喂养诱导的良好葡萄糖反应可能是由体重下降介导的；(3)肥胖和过量摄入亚油酸是糖耐量失调的独立危险因素。版权所有(C) 1996年由W.B.桑德斯公司
Mice fed a high-fat diet develop hyperglycemia and obesity. Using non-insulin-dependent diabetes mellitus (NIDDM) model mice, we investigated the effects of seven different dietary oils on glucose metabolism: palm oil, which contains mainly 45% palmitic acid (16:0) and 40% oleic acid (18:1); lard oil, 24% palmitic and 44% oleic acid; rapeseed oil, 59% oleic and 20% linoleic acid (18:2); soybean oil, 24% oleic and 54% linoleic acid; safflower oil, 76% linoleic acid; perilla oil, 58% or-linolenic acid; and tuna fish oil, 7% eicosapentaenoic acid and 23% docosahexaenoic acid. C57BL/6J mice received each as a high-fat diet (60% of total calories) for 19 weeks (n = 6 to 11 per group). After 19 weeks of feeding, body weight induced by the diets was in the following order: soybean > palm greater than or equal to lard greater than or equal to rapeseed greater than or equal to safflower greater than or equal to perilla greater than or equal to fish oil. Glucose levels 30 minutes after a glucose load were highest for safflower oil (congruent to 21.5 mmol/L), modest for rapeseed oil, soybean oil, and lard (congruent to 17.6 mmol/L), mild for perilla, fish, and palm oil (congruent to 13.8 mmol/L), and minimal for high-carbohydrate meals (congruent to 10.4 mmol/L). Only palm oil-fed mice showed fasting hyperinsulinemia (P < .001). By stepwise multiple regression analysis, body weight (or white adipose tissue [WAT] weight) and intake of linoleic acid (or n-3/n-6 ratio) were chosen as independent variables to affect glucose tolerance. By univariate analysis, the linoleic acid intake had a positive correlation with blood glucose level (r = .83, P = .02) but not with obesity (r = .46, P = .30). These data indicate that (1) fasting blood insulin levels vary among fat subtypes, and a higher fasting blood insulin level in palm oil-fed mice may explain their better glycemic control irrespective of their marked obesity; (2) a favorable glucose response induced by fish oil feeding may be mediated by a decrease of body weight; and (3) obesity and a higher intake of linoleic acid are independent risk factors for dysregulation of glucose tolerance. Copyright (C) 1996 by W.B. Saunders Company