Pattern of white matter abnormalities at MR imaging: Use of polymerase chain reaction testing of guthrie cards to link pattern with congenital cytomegalovirus infection
Pattern of white matter abnormalities at MR imaging: Use of polymerase chain reaction testing of guthrie cards to link pattern with congenital cytomegalovirus infection
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DOI：
10.1148/radiol.2302021459
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发表时间：
2004-02-01
期刊：
影响因子：
19.7
通讯作者：
Weel, AFL
中科院分区：
文献类型：
--
作者：
van der Knaap, MS;Vermeulen, G;Weel, AFL
目得：通过聚合酶链反应（PCR）检测新生儿血液中的巨细胞病毒（CMV）DNA，在古特里卡上进行验证，以确定提示先天性巨细胞病毒（CMV）感染的磁共振（MR）成像模式。根据8例先天性CMV感染患者的研究结果，作者制定了MR成像纳入标准，包括主要位于顶叶深部白色物质中的多病灶病变。如果存在脑回异常，则白色病变为多灶性或弥漫性。该标准适用于152例病因不明的静止性白质脑病患者。对43例符合MR成像标准的患者中的22例、20例不符合标准的患者和300例对照受试者的古特里卡进行了分析。应用Fisher精确检验评价MR影像学特征与CMV感染的相关性，应用后向消除线性判别分析在初始诊断标准的基础上，进一步确定MR影像学特征对CMV感染的预测价值。结果：22例疑似先天性CMV感染的患者中，12例PCR检测阳性，非疑似CMV感染的患者中无一例PCR检测阳性（P
PURPOSE: To define a magnetic resonance (MR) imaging pattern suggestive of congenital cytomegalovirus (CMV) infection by using polymerase chain reaction (PCR) testing to detect CMV DNA in neonatal blood on Guthrie cards for validation.MATERIALS AND METHODS: On the basis of findings in eight patients with documented congenital CMV infection, the authors developed MR imaging inclusion criteria, including multifocal lesions predominantly located in the deep parietal white matter. If gyral abnormalities were present, white matter lesions were either multifocal or diffuse. The criteria were applied to 152 patients with static leukoencephalopathy of unknown etiology. Guthrie cards for 22 of the 43 patients fulfilling the MR imaging criteria, 20 patients not fulfilling them, and 300 control subjects were analyzed. Fisher exact testing was used to evaluate the association between MR imaging characteristics and CMV status, and backward elimination linear discriminant analysis was used to identify MR imaging characteristics predictive of CMV infection in addition to the initial criteria.RESULTS: PCR test results were positive in 12 of 22 patients suspected of having congenital CMV infection, in no patient not suspected of having infection (P