The Caudal Migratory Stream: A Novel Migratory Stream of Interneurons Derived from the Caudal Ganglionic Eminence in the Developing Mouse Forebrain
The Caudal Migratory Stream: A Novel Migratory Stream of Interneurons Derived from the Caudal Ganglionic Eminence in the Developing Mouse Forebrain
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DOI：
10.1523/jneurosci.2072-05.2005
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发表时间：
2005-08
期刊：
影响因子：
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通讯作者：
M. Yozu;H. Tabata;K. Nakajima
中科院分区：
文献类型：
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作者：
M. Yozu;H. Tabata;K. Nakajima
来自神经节隆起（GE），特别是其尾部（CGE）的中间神经元的迁移路径，仍然基本上是未知的。为了阐明来自GE各部分的中间神经元的三维迁移概况，我们开发了一种涉及局灶性电穿孔到端脑半球的一个小的，定义的部分的技术。而内侧GE细胞迁移横向和广泛分布在整个皮质，大多数的CGE细胞向尾侧端脑的最尾端迁移。延时成像和体内免疫组织化学研究证实了一个迁移流的存在所描绘的群体CGE细胞尾侧，最终到达海马。移植实验表明，CGE细胞的尾部方向的迁移是内在的决定早在胚胎13.5天。尾侧迁移流是一种新的迁移路径的人口CGE衍生的中间神经元通过从下腭到海马。
The migratory paths of interneurons derived from the ganglionic eminence (GE), and particularly its caudal portion (CGE), remain essentially unknown. To clarify the three-dimensional migration profile of interneurons derived from each part of the GE, we developed a technique involving focal electroporation into a small, defined portion of the telencephalic hemisphere. While the medial GE cells migrated laterally and spread widely throughout the cortex, the majority of the CGE cells migrated caudally toward the caudal-most end of the telencephalon. Time-lapse imaging and an in vivo immunohistochemical study confirmed the existence of a migratory stream depicted by a population of CGE cells directed caudally that eventually reached the hippocampus. Transplantation experiments suggested that the caudal direction of migration of the CGE cells was intrinsically determined as early as embryonic day 13.5. The caudal migratory stream is a novel migratory path for a population of CGE-derived interneurons passing from the subpallium to the hippocampus.