A Natural Bone Cement-A Laboratory Novelty Led to the Development of Revolutionary New Biomaterials.
A Natural Bone Cement-A Laboratory Novelty Led to the Development of Revolutionary New Biomaterials.
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DOI：
10.6028/jres.106.053
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发表时间：
2001-11
影响因子：
1.5
通讯作者：
Takagi S
中科院分区：
文献类型：
--
作者：
Chow LC;Takagi S
1987 年，NIST 对磷酸钙化学的研究发现了世界上第一个自硬化磷酸钙水泥 (CPC)。通过实验室、动物和临床研究，将 CPC 开发成临床有用的生物材料。自硬化能力和高生物相容性的结合使 CPC 成为修复骨缺损的独特材料。这种生物材料的其他一些独特优点是水泥对缺损组织表面近乎完美的适应，以及逐渐吸收和新骨形成。 1996年，由磷酸四钙和无水磷酸二钙组成的CPC被美国食品和药物管理局（FDA）批准用于修复人类颅骨缺损，从而成为第一种可用于临床的此类材料。本文对CPC的发展历程、理化性质及临床应用进行综述。
Research on calcium phosphate chemistry at NIST led to the discovery of the worlds first self-hardening calcium phosphate cements (CPC) in 1987. Laboratory, animal, and clinical studies were conducted to develop CPC into clinically useful biomaterials. The combination of self-hardening capability and high biocompatibility makes CPC a unique material for repairing bone defects. Near perfect adaptation of the cement to the tissue surfaces in a defect, and a gradual resorption followed by new bone formation are some of the other distinctive advantages of this biomaterial. In 1996 a CPC, consisting of tetracalcium phosphate and dicalcium phosphate anhydrous, was approved by the Food and Drug Administration (FDA) for repairing cranial defects in humans, thus becoming the first material of its kind available for clinical use. This paper will review the course of the development, the physical and chemical properties, and clinical applications of CPC.