Synergistic associations between hookworm and other helminth species in a rural community in Brazil
Synergistic associations between hookworm and other helminth species in a rural community in Brazil
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DOI：
10.1111/j.1365-3156.2005.01541.x
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发表时间：
2006-01-01
影响因子：
3.3
通讯作者：
Bethony, JM
中科院分区：
文献类型：
--
作者：
Fleming, FM;Brooker, S;Bethony, JM
目的确定可能的协同协会钩虫和其他helminths.Method横断面调查的所有家庭在10公里（2）的Americaninhas，农村社区在米纳斯吉拉斯，巴西。我们确定了一个年龄分层样本的1332个人从335 house.Results钩虫是最流行的蠕虫感染（68.2%），其次是蛔虫（48.8%）和曼氏血吸虫（45.3%）的单一和多种蠕虫感染的患病率和强度。总体而言，60.6%的人患有混合蠕虫感染。多因素分析显示钩虫和沙门氏菌的合并感染与疾病的发生有显著的正相关。曼氏钩虫和曼氏钩虫混合感染。蚯蚓。钩虫和A.蚯蚓导致更高的卵计数，这表明这些物种之间的协同关系，虽然，我们发现了重要的年龄差异，在这种关系。但S. mansoni或A.结论本研究结果对蠕虫感染的流行病学、免疫学和防治具有重要意义。需要更多的研究来检查化疗后的再感染率和免疫反应，以及化疗在多大程度上改变了多寄生虫的影响。
OBJECTIVE To identify possible synergistic associations of hookworm and other helminths.METHOD Cross-sectional survey of all households within 10 km(2) of Americaninhas, a rural community in Minas Gerais, Brazil. We determined the prevalence and intensity of single and multiple helminth species infection in an age-stratified sample of 1332 individuals from 335 households.RESULTS Hookworm was the most prevalent helminth infection (68.2%), followed by Ascaris lumbricoides (48.8%) and Schistosoma mansoni (45.3%). Overall, 60.6% of individuals harboured mixed helminth infections. Multivariate analysis indicated significant positive associations for co-infection with hookworm and S. mansoni and for co-infection with hookworm and A. lumbricoides. Co-infections with hookworm and A. lumbricoides resulted in higher egg counts for both, suggesting a synergistic relationship between these species, although, we found important age differences in this relationship. However, the intensity of S. mansoni or A. lumbricoides co-infection did not differ from that of mono-infection.CONCLUSION These results have implications for the epidemiology, immunology and control of multiple helminth infections. More research is needed to examine the rates of re-infection and immune responses after chemotherapy, and to what extent the effects of polyparasitism are altered by chemotherapy.