Effect of estradiol and steroid analogues on the clearance of immunoglobulin G-coated erythrocytes.
Effect of estradiol and steroid analogues on the clearance of immunoglobulin G-coated erythrocytes.
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DOI：
10.1172/jci111669
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发表时间：
1985
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影响因子：
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通讯作者：
David;Friedman;Francis;Netti;Alan;D. Schreiber
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作者：
David;Friedman;Francis;Netti;Alan;D. Schreiber
尽管众所周知，女性中几种免疫系统疾病的发病率不成比例，但性类固醇对免疫过程的影响尚不清楚。我们使用动物模型来定量评估雌二醇和类固醇类似物对 IgG 包被红细胞免疫清除的影响，该模型有助于阐明皮质类固醇在体内的作用。虽然皮质类固醇会损害 IgG 包被的红细胞的清除率，但雌二醇的剂量与怀孕期间达到的剂量相当，却显着增强了清除率。然而，雌二醇并不能增强热变红细胞的脾脏清除能力。从雌二醇处理的动物中分离出的脾巨噬细胞对免疫球蛋白 G [Fc(IgG)] Fc 部分的受体亲和力增强，这种效应可能是体内清除率增强的原因。没有观察到雌二醇对脾巨噬细胞 C3 受体的一致影响。治疗 7 天后，合成雄激素达那唑、盐皮质激素脱氧皮质酮和皮质醇代谢物四氢可的松不会改变 IgG 包被细胞的清除率。雌激素拮抗剂/激动剂他莫昔芬增强了 IgG 包被细胞的清除率，但程度低于雌二醇。雌激素对巨噬细胞 Fc (IgG) 受体介导的清除的影响可能部分解释了荷尔蒙状态变化（例如怀孕）期间几种自身免疫性疾病临床表达的变化。
Although the disproportionate frequency of several immunologic disorders among women is well recognized, the effect of sex steroids on immunologic processes is unclear. We used an animal model, which has helped to elucidate the effect of corticosteroids in vivo, to quantitatively assess the effect of estradiol and steroid analogues on the immune clearance of IgG-coated erythrocytes. While corticosteroids impaired the clearance of IgG-coated erythrocytes, estradiol, in doses comparable to those achieved during pregnancy, significantly enhanced the clearance. Estradiol, however, did not enhance the splenic clearance of heat-altered erythrocytes. Splenic macrophages isolated from estradiol-treated animals expressed enhanced receptor affinity for the Fc portion of immunoglobulin G [Fc(IgG)], an effect probably responsible for the enhanced in vivo clearance. No consistent effect of estradiol on the splenic macrophage C3 receptors was observed. The synthetic androgen danazol, the mineralocorticoid deoxycorticosterone, and the cortisol metabolite tetrahydrocortisone did not alter the clearance of IgG-coated cells after 7 d of therapy. The estrogen antagonist/agonist tamoxifen enhanced the clearance of IgG-coated cells, but to a lesser extent than estradiol. An effect of estrogens on macrophage Fc (IgG) receptor-mediated clearance may explain in part the variation in clinical expression of several autoimmune disorders during changes in hormonal state, such as pregnancy.