Pseudopalisades in glioblastoma are hypoxic, express extracellular matrix proteases, and are formed by an actively migrating cell population
Pseudopalisades in glioblastoma are hypoxic, express extracellular matrix proteases, and are formed by an actively migrating cell population
复制标题
DOI：
10.1158/0008-5472.can-03-2073
复制
发表时间：
2004-02-01
期刊：
影响因子：
11.2
通讯作者：
Van Meir, EG
中科院分区：
文献类型：
--
作者：
Brat, DJ;Castellano-Sanchez, AA;Van Meir, EG
坏死和血管增生是区分最恶性的浸润性星形细胞瘤胶质母细胞瘤（GBM）与较低级别星形细胞瘤的病理特征。在GBM中，坏死灶周围通常有称为假性栅栏的高细胞区。虽然已知这些细胞分泌高水平的促进肿瘤生长的促血管生成因子，但其来源尚不明确。我们认为假性突起代表了星形细胞瘤细胞从缺氧/缺氧灶迁移的不同阶段和组织学样本，通常由中央血管闭塞事件触发。这一观点是基于我们的发现，假乳化瘤细胞的增殖能力比邻近的星形细胞瘤低5-50%，凋亡能力高6-20倍，这表明细胞积累不是由于增殖增加或对凋亡的抵抗。共存的炎症细胞解释了
Necrosis and vascular proliferation are the pathologic features that distinguish the most malignant infiltrative astrocytoma, glioblastoma (GBM), from those of lower grades. In GBM, hypercellular zones called pseudopalisades typically surround necrotic foci. Although these cells are known to secrete high levels of proangiogenic factors that promote tumor growth, their origins are ill defined. We propose that pseudopalisades represent differing stages and histologic samplings of astrocytoma cells migrating away from a hypoxic/anoxic focus, often triggered by a central vaso-occlusive event. This proposition is based on our findings that pseudopalisading cells are 5-50% less proliferative and 6-20 times more apoptotic than adjacent astrocytoma, indicating that cell accumulation does not result from increased proliferation or resistance to apoptosis. Coexisting inflammatory cells account for