Brain activation induced by estimation of duration: A PET study
Brain activation induced by estimation of duration: A PET study
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DOI：
10.1006/nimg.1996.0014
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发表时间：
1996-04-01
期刊：
影响因子：
5.7
通讯作者：
Comar, D
中科院分区：
文献类型：
--
作者：
Maquet, P;Lejeune, H;Comar, D
有关视觉刺激的持续时间信息需要处理，其他视觉特征（例如大小或强度）也需要处理。使用正电子发射断层扫描、迭代 (H2O)-O-15 输注和统计参数映射，我们研究了时间处理的神经相关性。九名正常受试者接受了六次连续 rCBF。研究了三个任务：（a）非时间泛化任务（D 任务），其中受试者必须判断（通过按两个键之一）绿色 LED 的照明持续时间是否等于或不同于先前提出的标准； (b) 强度泛化任务。 (I任务)其中判断涉及LED的强度； (c) 控制任务（C 任务），其中受试者必须随机按下两个键之一以响应 LED 照明。与 C 任务期间相比，D 任务期间的 rCBF 显着增加，在右侧前额皮质、右侧顶下小叶、前扣带皮层、蚓部和对应于左侧梭状回的区域中观察到。与 C 任务期间相比，I 任务期间的 rCBF 显着增加，在右侧前额皮质、右侧顶下小叶、右侧纹外皮质、前扣带皮层、左侧顶下小叶、蚓部和对应于梭状回的两个对称区域中观察到 rCBF 显着增加。与 I 任务相比，D 任务中没有观察到显着的激活。我们认为，这些皮质图最好是通过视觉注意力和记忆结构的招募来解释的，行为研究表明，视觉注意力和记忆结构在前瞻性时间判断中发挥着重要作用。数据还表明视觉刺激的时间维度是在属性中进行处理的。与其他视觉属性相同的区域。 (C) 1996 学术出版社
Duration information about a visual stimulus requires processing as do other visual features such as size or intensity. Using positron emission tomography, iterative (H2O)-O-15 infusions, and statistical parametric mapping, we investigated the neural correlates of time processing. Nine normal subjects underwent six serial rCBF. Three tasks were studied: (a) Atemporal generalization task (D task) in which the subjects had to judge (by pressing one of two keys) whether the duration of the illumination of a green LED was equal to or different from that of a previously presented standard; (b) An intensity generalization task. (I task) in which the judgment concerned the intensity of the LED; and (c) A control task (C task) in which the subjects had to press one of the two keys at random in response to LED illumination. A significant increase in rCBF during the D task, compared to that during the C task, was observed in right prefontal cortex, right inferior parietal lobule, anterior cingulate cortex, vermis, and a region corresponding to the left fusiform gyrus. A significant increase in rCBF during the I task, compared to that during the C task, was observed in right prefontal cortex, right inferior parietal lobule, right extrastriate cortex, anterior cingulate cortex, left inferior parietal lobule, vermis, and two symmetrical regions corresponding to the fusiform gyri. No significant activation was observed in the D task when compared to that in the I task. We propose that these cortical maps are best explained by the recruitment of visual attention and memory structures, which play a major role in prospective time judgements as indicated by behavioral studies. The data also suggest that the temporal dimension of a visual stimulus is processed in attributes. the same areas as other visual attributes. (C) 1996 Academic Press, Inc.