T cell adhesion mechanisms revealed by receptor lateral mobility
T cell adhesion mechanisms revealed by receptor lateral mobility
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DOI：
10.1002/bip.20898
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发表时间：
2008-05-01
期刊：
影响因子：
2.9
通讯作者：
Golan, David E.
中科院分区：
文献类型：
--
作者：
Cairo, Christopher W.;Golan, David E.
细胞表面受体介导细胞与其环境之间的信息交换。在粘附受体的情况下，受体的空间分布和分子缔合对其功能至关重要。因此，了解调节这些分子的分布和结合缔合的机制对于了解它们的功能调节是必要的。表征粘附受体的横向移动性的实验揭示了一组控制受体功能和细胞行为的共同机制。T细胞提供了细胞粘附的最具活力的例子之一。单个T细胞与抗原呈递细胞、血管内皮细胞和许多其他细胞类型进行无数的细胞间接触。我们在这里审查的机制，调节T细胞粘附受体的横向流动性作为一个窗口，这些系统的分子调控，我们提出了一个一般的框架，了解这些和其他细胞粘附系统之间可能是共同的原则和机制。我们认为，受体的横向流动性是通过四个主要机制，重组，招聘分散和锚定，我们审查具体的例子，T细胞粘附受体系统，利用这些机制中的一个或多个。(c)2007 Wiley Periodicals，Inc.
Cell surface receptors mediate the exchange of information between cells and their environment. In the case of adhesion receptors, the spatial distribution and molecular associations of the receptors are critical to their function. Therefore, understanding the mechanisms regulating the distribution and binding associations of these molecules is necessary to understand their functional regulation. Experiments characterizing the lateral mobility of adhesion receptors have revealed a set of common mechanisms that control receptor function and thus cellular behavior. The T cell provides one of the most dynamic examples of cellular adhesion. An individual T cell makes innumerable intercellular contacts with antigen presenting cells, the vascular endothelium, and many other cell types. We review here the mechanisms that regulate T cell adhesion receptor lateral mobility as a window into the molecular regulation of these systems, and we present a general framework for understanding the principles and mechanisms that are likely to be common among these and other cellular adhesion systems. We suggest that receptor lateral mobility is regulated via four major mechanisms-reorganization, recruitment dispersion, and anchoring-and we review specific examples of T cell adhesion receptor systems that utilize one or more of these mechanisms. (c) 2007 Wiley Periodicals, Inc.