BIOGENIC-AMINES AND SOME METALS IN BRAIN OF CADMIUM-EXPOSED DIABETIC RATS
BIOGENIC-AMINES AND SOME METALS IN BRAIN OF CADMIUM-EXPOSED DIABETIC RATS
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DOI：
10.1002/jat.2550050608
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发表时间：
1985-01-01
影响因子：
3.3
通讯作者：
HUSSAIN, T
中科院分区：
文献类型：
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作者：
CHANDRA, SV;KALIA, K;HUSSAIN, T
将糖尿病大鼠（四氧嘧啶型糖尿病）每天暴露于镉（2 mg kg-1 i.p） 21天，观察其血糖、生物胺和脑内铁、铜、锌和镉的水平。与单独接触镉或糖尿病大鼠相比，接触镉对糖尿病大鼠的高血糖效应和血液中镉的积累产生了显著的加剧。与镉暴露或糖尿病相比，镉暴露的糖尿病大鼠的脑多巴胺和5-羟色胺水平的升高也更为明显。接触镉对糖尿病大鼠的血液中铜的浓度也产生了显著的变化。这些结果表明镉对糖尿病大鼠的毒性增强。
Diabetic rats (alloxan diabetes) were exposed to cadmium (2 mg kg-1 i.p.) daily for 21 days to investigate the levels of blood glucose, biogenic amines and iron, copper, zinc and cadmium in the brain. Cadmium exposure to diabetic rats produced a significant exacerbation in the hyperglycemic effect and accumulation of cadmium in the blood compared with that observed after diabetes or cadmium exposure alone. The elevation in the levels of brain dopamine and 5-hydroxytryptamine were also more pronounced in cadmium-exposed diabetic rats compared with either cadmium exposure or diabetes alone. Cadmium exposure to diabetic rats also produced significant changes in the concentrations of copper in the blood. These results indicated enhanced cadmium toxicity in diabetic rats.