Rho/Rho-Kinase Pathway in Brain Stem Contributes to Blood Pressure Regulation via Sympathetic Nervous System
Rho/Rho-Kinase Pathway in Brain Stem Contributes to Blood Pressure Regulation via Sympathetic Nervous System
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脑干中的 Rho/Rho 激酶通路有助于通过交感神经系统调节血压
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发表时间：
2003
期刊：
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通讯作者：
AkiraTakeshita
中科院分区：
文献类型：
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作者：
KojiIto;YoshitakaHirooka;KojiSakai;TakuyaKishi;KozoKaibuchi;HiroakiShimokawa;AkiraTakeshita
最近的研究表明Rho/Rho激酶通路在多种细胞功能中起重要作用，包括肌动蛋白细胞骨架组织和血管平滑肌收缩。该通路也存在于中枢神经系统中，并且参与树突棘和轴突生长的维持以及神经递质释放的调节。然而，其在中枢血压调节中的作用尚不清楚。在本研究中，阻断Rho/Rho激酶通路在孤束核（NTS）的脑干，通过显微注射一种特定的Rho激酶抑制剂降低血压，心率，肾交感神经活动在Wistar-Kyoto（WKY）大鼠和自发性高血压大鼠（SHR）。然而，这些变量的减少幅度在SHR比WKY大鼠更大。此外，腺病毒载体编码显性阴性Rho激酶降低血压，心率，尿去甲肾上腺素排泄在两个...
Recent studies have demonstrated that the Rho/Rho-kinase pathway plays an important role in various cellular functions, including actin cytoskeleton organization and vascular smooth muscle contraction. This pathway is also present in the central nervous system and is involved in the maintenance of dendritic spines and axon outgrowth and in the regulation of neurotransmitter release. However, its role in central blood pressure regulation is unknown. In the present study, blockade of the Rho/Rho-kinase pathway in the nucleus tractus solitarii (NTS) of the brain stem by microinjection of a specific Rho-kinase inhibitor decreased blood pressure, heart rate, and renal sympathetic nerve activity in both Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). However, the magnitude of decreases in these variables was greater in SHR than in WKY rats. In addition, an adenovirus vector encoding dominant-negative Rho-kinase decreased blood pressure, heart rate, and urinary norepinephrine excretion in both...