Mast cell production and response to IL-4 and IL-13.
Mast cell production and response to IL-4 and IL-13.
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DOI：
10.1016/j.cyto.2015.05.019
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发表时间：
2015-09
期刊：
影响因子：
3.8
通讯作者：
Ryan JJ
中科院分区：
文献类型：
--
作者：
McLeod JJ;Baker B;Ryan JJ
IL-4被认为是肥大细胞首先产生的细胞因子，负责促进肥大细胞IL-13的产生。IL-4和IL-13在刺激和维持过敏反应中起着突出的作用。作为密切相关的基因，IL-4和IL-13具有共同的受体亚基IL-4Rα，这是信号传导所必需的。本文总结了肥大细胞活化与IL-4和IL-13产生相关的文献，包括下游信号传导。我们还描述了每种细胞因子在肥大细胞免疫中发挥的积极和消极作用，并详细说明了小鼠和人类肥大细胞对IL-4和IL-13的反应之间存在的差异。
IL-4 was identified as the first cytokine to be produced by mast cells and is responsible for promoting mast cell IL-13 production. IL-4 and IL-13 play a prominent role in stimulating and maintaining the allergic response. As closely related genes, IL-4 and IL-13 share a common receptor subunit, IL-4Rα, necessary for signaling. Here we summarize the literature on mast cell activation associated with IL-4 and IL-13 production, including downstream signaling. We also describe the positive and negative roles each cytokine plays in mast cell immunity and detail the differences that exist between mouse and human mast cell responses to IL-4 and IL-13.