Strategies for assessing the implications of malformed frogs for environmental health
Strategies for assessing the implications of malformed frogs for environmental health
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DOI：
10.2307/3454299
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发表时间：
2000-01-01
影响因子：
10.4
通讯作者：
Lucier, G
中科院分区：
文献类型：
--
作者：
Burkhart, JG;Ankley, G;Lucier, G
最近自然蛙类种群中畸形发生率的增加引起了人们对环境状况以及不明病原体对野生动物和人类种群健康的可能影响的关注。1997年12月4日至5日，在北卡罗来纳州研究三角公园的国家环境健康科学研究所举办了一次关于评估畸形青蛙对环境健康的影响的战略公开讲习班。讲习班的目的是在联邦和州一级对人类和环境健康具有科学兴趣和责任的多学科小组之间分享信息。讨论突出了与青蛙畸形直接相关的可能原因和最新发现，并提供了对若干领域适用于继续调查的问题和战略的见解。根据对野外两栖动物进行的诊断、可能导致观察到的畸形类型的生物机制以及平行的实验室和野外研究，对畸形的可能原因进行了评估。水文地球化学必须更多地纳入环境毒理学，因为水环境的关键作用以及相对于任何潜在暴露的面貌和运输的重要性。目前还没有迹象表明这些畸形是否与人类健康因素有关。然而，原因可能是水传播的，这表明需要确定相关因素，并在危险评估方面确定环境与人类健康之间的关系。
The recent increase in the incidence of deformities among natural frog populations has raised concern about the state of the environment and the possible impact of unidentified causative agents on the health of wildlife and human populations. An open workshop on Strategies for Assessing the Implications of Malformed Frogs for Environmental Health was convened on 4-5 December 1997 at the National Institute of Environmental Health Sciences in Research Triangle Park, North Carolina. The purpose of the workshop was to share information among a multidisciplinary group with scientific interest and responsibility for human and environmental health at the federal and state level. Discussions highlighted possible causes and recent findings directly related to frog deformities and provided insight into problems and strategies applicable to continuing investigation in several areas. Possible causes of the deformities were evaluated in terms of diagnostics performed on field amphibians, biologic mechanisms that can lead to the types of malformations observed, and parallel laboratory and field studies. Hydrogeochemistry must be more integrated into environmental toxicology because of the pivotal role of the aquatic environment and the importance of faces and transport relative to any potential exposure. There is no indication of whether there may be a human health factor associated with the deformities. However, the possibility that causal agents may be waterborne indicates a need to identify the relevant factors and establish the relationship between environmental and human health in terms of hazard assessment.