Prevalence and Immunophenotypic Characteristics of Monoclonal B-Cell Lymphocytosis in Healthy Korean Individuals With Lymphocytosis
Prevalence and Immunophenotypic Characteristics of Monoclonal B-Cell Lymphocytosis in Healthy Korean Individuals With Lymphocytosis
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健康韩国淋巴细胞增多症患者中单克隆 B 细胞淋巴细胞增多症的患病率和免疫表型特征
DOI：
10.3343/alm.2020.40.5.409
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发表时间：
2020
影响因子：
4.9
通讯作者：
D. Cho
中科院分区：
文献类型：
--
作者：
I. Yoo;Sung Hoan Bang;D. Lim;S. Kim;Kyunga Kim;Hee;Sun;D. Cho
在有限的地理区域进行了单克隆B细胞淋巴细胞增多症（MBL）的流行病学研究。关于MBL在亚洲的流行情况知之甚少。我们调查了年龄≥40岁的特发性淋巴细胞增多症（淋巴细胞计数>4.0×109/L）韩国人中MBL的患病率和免疫表型特征。在2018年6月至2019年8月期间访问韩国三星医疗中心健康促进中心的73，727名健康个体中，共有105份剩余外周血样本符合这些标准。使用八色流式细胞术分析样本，采用以下单克隆抗体：CD 45、CD 5、CD 10、CD 19、CD 20、CD 23以及κ和λ轻链。研究人群中MBL的总体患病率为2.9%（3/105）;有1例慢性淋巴细胞白血病（CLL）样MBL（CD 5 + CD 23+），1例非典型CLL样MBL（CD 5 + CD 23 −）和1例具有λ限制性模式的CD 5 −MBL。这是第一次在东亚人群中对MBL患病率的研究，它揭示了在患有淋巴细胞增多症的健康韩国人中MBL的患病率相对较低。
Epidemiological studies of monoclonal B-cell lymphocytosis (MBL) have been conducted in limited geographical regions. Little is known about the prevalence of MBL in Asia. We investigated the prevalence and immunophenotypic characteristics of MBL in Koreans who had idiopathic lymphocytosis (lymphocyte count >4.0×109/L) and were ≥40 years of age. A total of 105 leftover peripheral blood samples met these criteria among those from 73,727 healthy individuals who visited the Health Promotion Center, Samsung Medical Center, Korea, from June 2018 to August 2019. The samples were analyzed using eight-color flow cytometry with the following monoclonal antibodies: CD45, CD5, CD10, CD19, CD20, CD23, and kappa and lambda light chains. The overall prevalence of MBL in the study population was 2.9% (3/105); there was one case of chronic lymphocytic leukemia (CLL)-like MBL (CD5+CD23+), one case of atypical CLL-like MBL (CD5+CD23−), and one case of CD5−MBL with a lambda restriction pattern. This is the first study on the MBL prevalence in an East Asian population, and it reveals a relatively low prevalence of MBL in healthy Korean individuals with lymphocytosis.