A flexible forward simulator for populations subject to selection and demography
A flexible forward simulator for populations subject to selection and demography
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DOI：
10.1093/bioinformatics/btn522
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发表时间：
2008-12-01
期刊：
影响因子：
5.8
通讯作者：
Hernandez, Ryan D.
中科院分区：
文献类型：
--
作者：
Hernandez, Ryan D.
本文介绍了一种新的前向种群遗传模拟程序，可以有效地产生样本的人口复杂的历史下的各种自然选择模型的人口。该程序（SFS_CODE）是高度灵活的，允许用户模拟现实的基因组区域与几个基因座根据各种突变模型（从简单到上下文相关）的演变，并允许插入和删除。每个基因座可以注释为编码或非编码，性连锁或常染色体，选择或中性，并具有任意连锁结构（从完全连锁到独立）。
This article introduces a new forward population genetic simulation program that can efficiently generate samples from populations with complex demographic histories under various models of natural selection. The program (SFS_CODE) is highly flexible, allowing the user to simulate realistic genomic regions with several loci evolving according to a variety of mutation models (from simple to context-dependent), and allows for insertions and deletions. Each locus can be annotated as either coding or non-coding, sex-linked or autosomal, selected or neutral, and have an arbitrary linkage structure (from completely linked to independent).