Residual tumor cells are unique cellular targets in glioblastoma.

Residual tumor cells are unique cellular targets in glioblastoma.
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DOI:
10.1002/ana.22036
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发表时间:
2010-08
影响因子:
11.2
通讯作者:
Scheffler, Bjoern
Scheffler, Bjoern
中科院分区:
医学1区
文献类型:
--
作者:
Glas, Martin;Rath, Barbara H.;Simon, Matthias;Reinartz, Roman;Schramme, Anja;Trageser, Daniel;Eisenreich, Ramona;Leinhaas, Anke;Keller, Mihaela;Schildhaus, Hans-Ulrich;Garbe, Stephan;Steinfarz, Barbara;Pietsch, Torsten;Steindler, Dennis A.;Schramm, Johannes;Herrlinger, Ulrich;Bruestle, Oliver;Scheffler, Bjoern

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每次胶质母细胞瘤(GBM)切除后,残留的肿瘤细胞仍在边缘处。它们对术后治疗的抵抗被认为是死亡率的主要驱动力,但它们的生物学特性在很大程度上仍未被描述。在本研究中,通过标准神经外科手术后切除边缘的实验性活检获得残留肿瘤细胞,并与常规切除肿瘤组织的样本进行直接比较。体外分析增殖、侵袭、干细胞质量、gbm典型抗原、基因型以及体外药物和辐照挑战研究表明,这些细胞是独特的实体。我们的研究结果表明,需要对残留肿瘤细胞进行表征,以优化GBM的诊断和治疗。
Residual tumor cells remain beyond the margins of every glioblastoma (GBM) resection. Their resistance to postsurgical therapy is considered a major driving force of mortality, but their biology remains largely uncharacterized. In this study, residual tumor cells were derived via experimental biopsy of the resection margin after standard neurosurgery for direct comparison with samples from the routinely resected tumor tissue. In vitro analysis of proliferation, invasion, stem cell qualities, GBM-typical antigens, genotypes, and in vitro drug and irradiation challenge studies revealed these cells as unique entities. Our findings suggest a need for characterization of residual tumor cells to optimize diagnosis and treatment of GBM.
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作者:
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